ReviewAnimals : an open access journal from MDPI2022
Evolution of the Concepts of Endometrosis, Post Breeding Endometritis, and Susceptibility of Mares.
Review in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- Endometritis and endometrial fibrosis are associated with alterations in mare endometrial proteome.BMC veterinary research · 2026Article
- Beyond Routine Ultrasonography: Peri-Insemination Biomarkers in Relation to Reproductive Competence in Warmblood Mares.Animals : an open access journal from MDPI · 2026Article
- The Equine Reproductive Microbiota: Composition, Dynamics, Dysbiosis, and Implications for Fertility in Mares and Stallions.Animals : an open access journal from MDPI · 2026Review
- Amniotic Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles for Equine Chronic Degenerative Endometritis Treatment.Veterinary medicine and science · 2026Article
- The Apparent pH Stability of Antibiotic Preparations Used for Uterine Infusions in Mares.Animals : an open access journal from MDPI · 2026Article
- Exploring the role of epigenetics in the processes related to the development of endometrosis in the mare.The Journal of reproduction and development · 2026Review
- Transcriptomic Insights into Tumor Necrosis Factor α's Role in the Fibrosis-Related Processes of Equine Endometrial Fibroblasts.International journal of molecular sciences · 2025Article
- Th1 and Th2 cells in equine endometrosis and their interactions with endometrial fibroblasts.Scientific reports · 2025Article
- Powerflow Doppler Ultrasonography in the Evaluation of Mares with and Without Endometritis.Veterinary sciences · 2025Article
- In vitro antimicrobial activity of non-traditional therapies for infectious endometritis in mares.Equine veterinary journal · 2025Article
- The myometrial transcriptome changes in mares with endometrosis.Scientific reports · 2025Article
- Shifts between pro-inflammatory and anti-inflammatory profiles in pregnant mares: a review of physiological functions.Frontiers in veterinary science · 2025Review
- Fundamentals of microbiome-based therapies for reproductive tract inflammatory diseases in domestic animals.Animal reproduction · 2025Review
- The effect of lysophosphatidic acid on myometrial contractility and the mRNA transcription of its receptors in the myometrium at different stages of endometrosis in mares.BMC veterinary research · 2024Article
- Extracellular vesicles secreted by equine adipose mesenchymal stem cells preconditioned with transforming growth factor β-1 are enriched in anti-fibrotic miRNAs and inhibit the expression of fibrotic genes in an in vitro system of endometrial stromal cells fibrosis.The veterinary quarterly · 2024Article
- Reproductive Disorders in Donkeys: Current Evidence and Update.Animals : an open access journal from MDPI · 2024Review
- Assessment of Connective Tissue in the Equine Uterus and Cervix: Review of Clinical Impact and Staining Options.Animals : an open access journal from MDPI · 2024Review
- The path to fertility: Current approaches to mare endometritis and endometrosis.Animal reproduction · 2024Article
- Prostaglandin pathways in equine myometrium regulations: endometrosis progression.Frontiers in veterinary science · 2024Article
- Equine Placentitis in Mares Induces the Secretion of Pro-Inflammatory CytokineVeterinary sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, the evolution of our understanding about post breeding endometritis (PBE), the susceptibility of mares, and events leading to endometrosis are reviewed. When sperm arrive in the uterus, pro-inflammatory cytokines and chemokines are released. They attract neutrophils and induce modulatory cytokines which control inflammation. In susceptible mares, this physiological defense can be prolonged since the pattern of cytokine release differs from that of resistant mares being delayed and weaker for anti-inflammatory cytokines. Delayed uterine clearance due to conformational defects, deficient myometrial contractions, and failure of the cervix to relax is detected by intrauterine fluid accumulation and is an important reason for susceptibility to endometritis. Multiparous aged mares are more likely to be susceptible. Untreated prolonged PBE can lead to bacterial or fungal endometritis called persistent or chronic endometritis. Exuberant or prolonged neutrophilia and cytokine release can have deleterious and permanent effects in inducing endometrosis. Interactions of neutrophils, cytokines, and prostaglandins in the formation of collagen and extracellular matrix in the pathogenesis of fibrosis are discussed. Endometritis and endometrosis are interconnected, influencing each other. It is suggested that they represent epigenetic changes induced by age and hostile uterine environment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.