Development of Next-Generation Probiotics by Investigating the Interrelationships between Gastrointestinal Microbiota and Diarrhea in Preruminant Holstein Calves.

Shih-Te Chuang, Chien-Ting Chen, Jui-Chun Hsieh, Kuan-Yi Li, Shang-Tse Ho, Ming-Ju Chen

Open access · goldAbstract read

In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

1.3field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 17 citations in OpenAlex.

Changes in the gut microbiome due to diarrhea in neonatal Korean indigenous calves.Frontiers in microbiology · 2025
Article
Analysis of Fecal Microbial Changes in Young Calves Following Bovine Rotavirus Infection.Veterinary sciences · 2023
Article
Sodium acetate/sodium butyrate alleviates lipopolysaccharide-induced diarrhea in miceFrontiers in microbiology · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Shih-Te ChuangDepartment of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 402204, Taiwan.ORCID 0000-0001-7758-8373

Chien-Ting ChenDepartment of Animal Science and Technology, National Taiwan University, Taipei 106037, Taiwan.

Jui-Chun HsiehDepartment of Animal Science and Technology, National Taiwan University, Taipei 106037, Taiwan.

Kuan-Yi LiDepartment of Animal Science and Technology, National Taiwan University, Taipei 106037, Taiwan.ORCID 0000-0002-6063-1803

Shang-Tse HoDepartment of Wood Based Materials and Design, National Chiayi University, Chiayi 600355, Taiwan.

Ming-Ju ChenDepartment of Animal Science and Technology, National Taiwan University, Taipei 106037, Taiwan.ORCID 0000-0003-4403-6112

National Taiwan University of Science and Technology · TWNational Chiayi University · TWNational Chung Hsing University · TW

Funding

the Ministry of Science and Technology of Taiwan MOST 105-2313-B-002-041-MY3 and MOST 109-2321-B-002-054

6 · The paper itself

Abstract

(1) Background: We aimed to isolate and identify potential next-generation probiotics (NGP) by investigating the interrelationships between gastrointestinal microbiota and diarrhea in preruminant Holstein calves. (2) Material and methods: Twenty preruminant Holstein calves were divided into healthy and diarrheic groups after the combination outcomes of veterinary diagnosis and fecal scores. The fecal microbiome, plasma cytokines, plasma immunoglobulin (Ig) G and haptoglobin were analyzed. The potential probiotic bacteria were identified by comparing the microbiota difference between healthy and diarrheic calves and correlation analysis with fecal scores and inflammatory markers. The identified bacteria were also isolated for further evaluation for antimicrobial activities and immunoregulatory effects. (3) Results: Microbiota analysis suggested that

Indexed as

Bifidobacterium longum subsp. longumHolstein calvesmicrobiotanext-generation probiotics

Identifiers

PMID35327091

DOI10.3390/ani12060695

PMCPMC8944458

OpenAlexW4221047845

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.