ReviewHealthcare (Basel, Switzerland)2022
RETRACTED: Ketamine in Acute Brain Injury: Current Opinion Following Cerebral Circulation and Electrical Activity.
Review in Healthcare (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Electrocardiogram alterations in non-traumatic brain injury: a systematic review.Journal of clinical monitoring and computing · 2024Pooled it
- Glymphatic System a Window on TBI Pathophysiology: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Variations in S-100Β and Neuron-Specific Enolase Levels During Functional Endoscopic Sinus Surgery Under Moderately Controlled Hypotension Using Four Distinct Anesthetic Protocols: A Randomized Controlled Study.Medicina (Kaunas, Lithuania) · 2026Trial
- Impact of Low-Dose Ketamine Infusion on Intracranial Pressure and Hemodynamics in Septic Shock Patients.Neurocritical care · 2026Trial
- Characterization of intracranial pressure variations in ventricular and subarachnoid spaces of the rat brain.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Modern management of maxillofacial trauma in the emergency department.World journal of emergency medicine · 2026Review
- Sedation and analgesia strategies in the neuro intensive care unit.World journal of critical care medicine · 2025Review
- Perioperative Management of Patients With Seizure Disorders: Part II.Anesthesia progress · 2025Review
- Ketamine's Role in Neuroinflammation and Neuroprotection Across Neurological and Psychiatric Disorders: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- A Personalized Approach to Maintaining Brain Drainage: A Case Series with a Technical Note.Journal of personalized medicine · 2025Article
- Review
- Effects of Subanesthetic Intravenous Ketamine Infusion on Stress Hormones and Synaptic Density in Rats with Mild Closed-Head Injury.Biomedicines · 2025Article
- Effectiveness of Intranasal Analgesia in the Emergency Department.Medicina (Kaunas, Lithuania) · 2023Review
- Effects of a Subanesthetic Ketamine Infusion on Inflammatory and Behavioral Outcomes after Closed Head Injury in Rats.Bioengineering (Basel, Switzerland) · 2023Article
- Severe Trauma-Induced Coagulopathy: Molecular Mechanisms Underlying Critical Illness.International journal of molecular sciences · 2023Review
- Modern Sedation and Analgesia Strategies in Neurocritical Care.Current neurology and neuroscience reports · 2023Review
- Acute Traumatic Pain in the Emergency Department.Diseases (Basel, Switzerland) · 2023Review
- External Ventricular Drainage: A Practical Guide for Neuro-Anesthesiologists.Clinics and practice · 2023Review
- Double relief: A systematic review and meta-analysis of intravenous ketamine and morphine combination for acute trauma analgesia.Journal of anaesthesiology, clinical pharmacologyArticle
- Clinical outcomes of ketamine in patients with traumatic brain injury: A systematic review.International journal of critical illness and injury scienceReview
Corrections and comments
- Retracted
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of ketamine in patients with TBI has often been argued due to its possible deleterious effects on cerebral circulation and perfusion. Early studies suggested that ketamine could increase intracranial pressure, decreasing cerebral perfusion pressure and thereby reducing oxygen supply to the damaged cerebral cortex. Some recent studies have refuted these conclusions relating to the role of ketamine, especially in patients with TBI, showing that ketamine should be the first-choice drug in this type of patient at induction. Our narrative review collects evidence on ketamine's use in patients with TBI. Databases were examined for studies in which ketamine had been used in acute traumatic brain injury (TBI). The outcomes considered in this narrative review were: mortality of patients with TBI; impact on intracranial pressure and cerebral perfusion pressure; blood pressure and heart rate values; depolarization rate; and preserved neurological functions. 11 recent studies passed inclusion and exclusion criteria and were included in this review. Despite all the benefits reported in the literature, the use of ketamine in patients with brain injury still appears to be limited. A slight increase in intracranial pressure was found in only two studies, while two smaller studies showed a reduction in intracranial pressure after ketamine administration. There was no evidence of harm from the ketamine's use in patients with TBI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.