Evidence map›Paper›PMID 35326835›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Clinical and Microbiological Effects of an Antimicrobial Stewardship Program in Urology-A Single Center Before-After Study.

Oana Joean, Daniel Tahedl, Madita Flintrop, Thorben Winkler, Ruxandra Sabau, Tobias Welte, Markus A Kuczyk, Ralf-Peter Vonberg, Jessica Rademacher

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Oana JoeanDepartment of Respiratory Medicine, Hannover Medical School, 1st Carl-Neuberg Street, 30625 Hannover, Germany.ORCID 0000-0002-5995-4605
Daniel TahedlDepartment of Urology and Urologic Oncology, Hannover Medical School, 1st Carl-Neuberg Street, 30625 Hannover, Germany.
Madita FlintropDepartment of Urology and Urologic Oncology, Hannover Medical School, 1st Carl-Neuberg Street, 30625 Hannover, Germany.
Thorben WinklerDepartment of Urology and Urologic Oncology, Hannover Medical School, 1st Carl-Neuberg Street, 30625 Hannover, Germany.
Ruxandra SabauInstitute for Clinical Pharmacology, Hannover Medical School, 1st Carl-Neuberg Street, 30625 Hannover, Germany.
Tobias WelteDepartment of Respiratory Medicine, Hannover Medical School, 1st Carl-Neuberg Street, 30625 Hannover, Germany.
Markus A KuczykDepartment of Urology and Urologic Oncology, Hannover Medical School, 1st Carl-Neuberg Street, 30625 Hannover, Germany.
Ralf-Peter VonbergInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 1st Carl-Neuberg Street, 30625 Hannover, Germany.ORCID 0000-0001-7706-8511
Jessica RademacherDepartment of Respiratory Medicine, Hannover Medical School, 1st Carl-Neuberg Street, 30625 Hannover, Germany.
Medizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is a major public health issue caused by antibiotic overuse and misuse. Antimicrobial stewardship (AMS) has been increasingly endorsed worldwide, but its effect has been studied scarcely in urologic settings. A before-after study was performed from 2018 through 2020 to evaluate changes in antimicrobial prescription, resistance rates and clinical safety upon implementation of an AMS audit and feedback program in the Urology Department of a large German academic medical center. The primary endpoints were safety clinical outcomes: the rate of infection-related readmissions and of infectious complications after transrectal prostate biopsies. Resistance rates and antimicrobial consumption rates were the secondary endpoints. The AMS team reviewed 196 cases (12% of all admitted in the department). The overall antibiotic use dropped by 18.7%. Quinolone prescriptions sank by 78.8% (p = 0.02) and 69.8% (p > 0.05) for ciprofloxacin and levofloxacin, respectively. The resistance rate of E. coli isolates declined against ceftriaxone (−9%), ceftazidime (−12%) and quinolones (−25%) in the AMS period. No significant increase in infection-related readmissions or infectious complications after prostate biopsies was observed (p = 0.42). Due to the potential to reduce antibiotic use and resistance rates with no surge of infection-related complications, AMS programs should be widely implemented in urologic departments.

Indexed as

antibioticsantimicrobial resistanceantimicrobial stewardshipquinoloneurology

Identifiers

PMID35326835
PMCPMC8944612
OpenAlexW4221116073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.