Evidence map›Paper›PMID 35326772›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Antibiotic Prescribing in Dutch Daytime and Out-of-Hours General Practice during the COVID-19 Pandemic: A Retrospective Database Study.

Karin Hek, Lotte Ramerman, Yvette M Weesie, Anke C Lambooij, Maarten Lambert, Marianne J Heins, Janneke M T Hendriksen, Robert A Verheij, Jochen W L Cals, Liset van Dijk

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Trends inAntibiotics (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Contacts in general practice during the COVID-19 pandemic: a register-based study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karin HekNivel, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN Utrecht, The Netherlands.ORCID 0000-0001-9551-1564
Lotte RamermanNivel, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN Utrecht, The Netherlands.
Yvette M WeesieNivel, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN Utrecht, The Netherlands.
Anke C LambooijIVM, The Dutch Institute for Rational Use of Medicine, P.O. Box 3089, 3502 GB Utrecht, The Netherlands.ORCID 0000-0002-3384-9858
Maarten LambertUnit of PharmacoTherapy, Groningen Research Institute of Pharmacy, Epidemiology & Economics, University of Groningen, P.O. Box 72, 9700 AB Groningen, The Netherlands.
Marianne J HeinsNivel, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN Utrecht, The Netherlands.ORCID 0000-0002-1794-7407
Janneke M T HendriksenNivel, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN Utrecht, The Netherlands.ORCID 0000-0001-9724-3137
Robert A VerheijNivel, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN Utrecht, The Netherlands.
Jochen W L CalsDepartment of Family Medicine, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
Liset van DijkNivel, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN Utrecht, The Netherlands.ORCID 0000-0003-3277-4740

Funding

Ministry of Health, Welfare and Sports, the Netherlands NA
6 · The paper itself

Abstract

COVID-19 restrictions have resulted in major changes in healthcare, including the prescribing of antibiotics. We aimed to monitor antibiotic prescribing trends during the COVID-19 pandemic in Dutch general practice, both during daytime and out-of-hours (OOH). Routine care data were used from 379 daytime general practices (DGP) and 28 OOH-services over the period 2019-2021. Per week, we analyzed prescription rates per 100,000 inhabitants, overall, for respiratory and urinary tract infections (RTIs and UTIs) specifically and within age categories. We assessed changes in antibiotic prescribing during different phases of the pandemic using interrupted time series analyses. Both at DGPs and OOH-services significantly fewer antibiotics were prescribed during the COVID-19 pandemic after government measures became effective. Furthermore, the number of contacts decreased in both settings. When restrictions were revoked in 2021 prescription rates increased both at DGP and OOH-services, returning to pre-pandemic levels at OOH-services, but not in DGP. Changes in antibiotic prescribing rates were prominent for RTIs and among children up to 11 years old, but not for UTIs. To conclude, while antibiotic prescribing decreased during the first year of the COVID-19 pandemic both in daytime and out-of-hours, the pandemic does not seem to have a lasting effect on antibiotic prescribing.

Indexed as

antibioticsantimicrobial resistanceCOVID-19general practiceout-of-hoursrestrictions

Identifiers

PMID35326772
PMCPMC8944515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.