ReviewAntibiotics (Basel, Switzerland)2022
Duration of Perioperative Antibiotic Prophylaxis in Open Fractures: A Systematic Review and Critical Appraisal.
Review in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Two-day versus three-day systemic antibiotic prophylaxis for Gustilo-Anderson type IIIA and IIIB open tibial fractures (PROACT): a randomised controlled trial.The Lancet regional health. Southeast Asia · 2026Article
- Epidemiological investigation and clinical characteristics study of orthopedic infections caused by Aeromonas in the southeast coastal region from 2018 to 2024.BMC infectious diseases · 2025Article
- Revisiting the OTA-OFC: a systematic review of open fracture classification studies since 2010.OTA international : the open access journal of orthopaedic trauma · 2025Article
- Delayed delivery of antibiotics by ultrasound-mediated rupture of polylactic acid pockets: In vitro and in vivo studies.PloS one · 2025Article
- Magnetic Nanocomposite Hydrogels in Orthopedics: Applications and Perspectives.International journal of nanomedicine · 2025Review
- Constructing a nomogram for the recurrence of tibial osteomyelitis after debridement surgery based on platelet to lymphocyte ratio at admission: a dual-center retrospective study from China.BMC musculoskeletal disorders · 2024Article
- Worrying Presence of Asymptomatic Bacterial Colonisation on Implanted Orthopedic Devices.Cureus · 2024Article
- RETRACTED: Effects of negative pressure wound therapy on wound infection and healing in patients with open fracture wounds: A meta-analysis.International wound journal · 2024Article
- Surgical site application of antibiotics: A potential game changer for fracture-related infection care and antibiotic stewardship.Journal of orthopaedics · 2023Article
- Comparative analysis of pathogen distribution in patients with fracture-related infection and periprosthetic joint infection: a retrospective study.BMC musculoskeletal disorders · 2023Article
- Fracture-related infection.Nature reviews. Disease primers · 2022Review
- The impact of a multidisciplinary team on the management of fracture-related infections: A surveillance study in Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fracture-related infection (FRI) remains a serious complication in open fracture care. Adequate surgical treatment and perioperative antibiotic prophylaxis (PAP) are key factors influencing the outcome. However, data concerning the optimal duration of PAP is scarce. The aim of this systematic review was to provide an overview of current evidence on the association between PAP duration and FRI in open fractures. A comprehensive search on 13 January 2022, in Embase, Medline, Cochrane, Web of Science and Google Scholar revealed six articles. Most studies compared either 1 day versus 5 days of PAP or included a cut-off at 72 h. Although prolonged PAP was not beneficial in the majority of patients, the variety of antibiotic regimens, short follow-up periods and unclear description of outcome parameters were important limitations that were encountered in most studies. This systematic review demonstrates a lack of well-constructed studies investigating the effect of PAP duration on FRI. Based on the available studies, prolonged PAP does not appear to be beneficial in the prevention of FRI in open fractures. However, these results should be interpreted with caution since all included studies had limitations. Future randomized trials are necessary to answer this research question definitively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.