Evidence map›Paper›PMID 35326716›Full record

ArticleCancers2022

Regulation of a Novel Splice Variant of Early Growth Response 4 (EGR4-S) by HER+ Signalling and HSF1 in Breast Cancer.

Jeremy M Drake, Benjamin J Lang, Martin Eduardo Guerrero-Gimenez, Jack Bolton, Christopher A Dow, Stuart K Calderwood, John T Price, Chau H Nguyen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Joint Screening for Ultra-High Dimensional Multi-Omics Data.Bioengineering (Basel, Switzerland) · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Jeremy M DrakeProMetTre Cancer Research, Melbourne 3205, Australia.ORCID 0000-0002-5874-2758
Benjamin J LangDepartment of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Martin Eduardo Guerrero-GimenezLaboratory of Oncology, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), National Scientific and Technical Research Council (CONICET), Mendoza 5500, Argentina.
Jack BoltonCollege of Health and Biomedicine, Victoria University, Melbourne 8001, Australia.
Christopher A DowDorevitch Pathology, Western Hospital, Melbourne 3011, Australia.
Stuart K CalderwoodDepartment of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
John T PriceCollege of Health and Biomedicine, Victoria University, Melbourne 8001, Australia.
Chau H NguyenCollege of Health and Biomedicine, Victoria University, Melbourne 8001, Australia.
Beth Israel Deaconess Medical Center · USVictoria University · AUConsejo Nacional de Investigaciones Científicas y Técnicas · ARMonash University · AUThe University of Melbourne · AUWestern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The zinc finger transcription factor EGR4 has previously been identified as having a critical role in the proliferation of small cell lung cancer. Here, we have identified a novel, shortened splice variant of this transcription factor (EGR4-S) that is regulated by Heat Shock Factor-1 (HSF1). Our findings demonstrate that the shortened variant (EGR4-S) is upregulated with high EGFR, HER2, and H-Ras

Indexed as

breast cancerEGR4HER2HSF1molecular stress

Identifiers

PMID35326716
PMCPMC8946690
OpenAlexW4220926111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.