Evidence map›Paper›PMID 35326714›Full record

ArticleCancers2022

Metabolic Profiling of Thymic Epithelial Tumors Hints to a Strong Warburg Effect, Glutaminolysis and Precarious Redox Homeostasis as Potential Therapeutic Targets.

Mohammad Alwahsh, Robert Knitsch, Rosemarie Marchan, Jörg Lambert, Christian Hoerner, Xiaonan Zhang, Berthold Schalke, De-Hyung Lee, Elena Bulut, Thomas Graeter and 11 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  10. Metabolic signatures of thymomas: potential biomarkers and treatment targets.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 3 countries.

Mohammad AlwahshLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., 44139 Dortmund, Germany.
Robert KnitschLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., 44139 Dortmund, Germany.
Rosemarie MarchanDepartment of Toxicology, Leibniz Research Center for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
Jörg LambertLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., 44139 Dortmund, Germany.
Christian HoernerInstitute of Pathology and Medical Research Center (ZMF), University Medical Center Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Xiaonan ZhangInstitute of Pathology and Medical Research Center (ZMF), University Medical Center Mannheim, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0003-4040-1784
Berthold SchalkeDepartment of Neurology, University of Regensburg, 93053 Regensburg, Germany.
De-Hyung LeeDepartment of Neurology, University of Regensburg, 93053 Regensburg, Germany.
Elena BulutDepartment of Thoracic Surgery, Thoraxklinik at Heidelberg University Hospital, 69120 Heidelberg, Germany.
Thomas GraeterThoracic Surgery, Clinic Löwenstein, 74245 Löwenstein, Germany.
German OttDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete-Fischer-Bosch Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.
Katrin S KurzDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete-Fischer-Bosch Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.
Gerhard PreisslerDepartment of Thoracic Surgery, RBK Lungenzentrum Stuttgart, Robert Bosch Hospital, Clinic Schillerhoehe, 70839 Gerlingen, Germany.
Sebastian SchölchJCCU Translational Surgical Oncology (A430), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0003-0012-3177
Joviana FarhatDepartment of Pharmacy, Faculty of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 122612, United Arab Emirates.
Zhihan YaoInstitute of Pathology and Medical Research Center (ZMF), University Medical Center Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Carsten StichtNGS Core Facility, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Philipp StröbelInstitute of Pathology, University Medical Center Göttingen, University of Göttingen, 37075 Göttingen, Germany.
Roland HergenröderLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., 44139 Dortmund, Germany.
Alexander MarxInstitute of Pathology and Medical Research Center (ZMF), University Medical Center Mannheim, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0001-9722-2483
Djeda BelharazemInstitute of Pathology and Medical Research Center (ZMF), University Medical Center Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Heidelberg University · DELeibniz Institute for Analytical Sciences - ISAS · DERobert Bosch Hospital · DEUniversity of Regensburg · DEAl Ain University · AEAl-Zaytoonah University of Jordan · JOGerman Cancer Research Center · DELöwenstein Medical (Germany) · DETU Dortmund University · DEUniversitätsmedizin Göttingen · DE

Funding

Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen, and the Bundesministerium für Bildung und Forschung 01KU1216I
6 · The paper itself

Abstract

Thymomas and thymic carcinomas (TC) are malignant thymic epithelial tumors (TETs) with poor outcome, if non-resectable. Metabolic signatures of TETs have not yet been studied and may offer new therapeutic options. Metabolic profiles of snap-frozen thymomas (WHO types A, AB, B1, B2, B3,

Indexed as

biomarkerHRMAS 1H-NMRmetabolomicsthymic carcinomathymoma

Identifiers

PMID35326714
PMCPMC8945961
OpenAlexW4221123664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.