Evidence map›Paper›PMID 35326711›Full record

ReviewCancers2022

From Biology to Treatment of Monoclonal Gammopathies of Neurological Significance.

Andrea Visentin, Stefano Pravato, Francesca Castellani, Marta Campagnolo, Francesco Angotzi, Chiara Adele Cavarretta, Alessandro Cellini, Valeria Ruocco, Alessandro Salvalaggio, Alessandra Tedeschi and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. A Comprehensive Review of Monoclonal Gammopathy of Undetermined Significance.Journal of the advanced practitioner in oncology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Neurological manifestations of MGUS.Hematology. American Society of Hematology. Education Program · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Andrea VisentinHematology and Clinical Immunology Unit, Department of Medicine, University of Padova, 35128 Padova, Italy.ORCID 0000-0003-0271-7200
Stefano PravatoHematology and Clinical Immunology Unit, Department of Medicine, University of Padova, 35128 Padova, Italy.
Francesca CastellaniNeurology Unit, Department of Neurosciences, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-4590-2548
Marta CampagnoloNeurology Unit, Department of Neurosciences, University of Padova, 35128 Padova, Italy.
Francesco AngotziHematology and Clinical Immunology Unit, Department of Medicine, University of Padova, 35128 Padova, Italy.
Chiara Adele CavarrettaHematology and Clinical Immunology Unit, Department of Medicine, University of Padova, 35128 Padova, Italy.
Alessandro CelliniHematology and Clinical Immunology Unit, Department of Medicine, University of Padova, 35128 Padova, Italy.
Valeria RuoccoHematology and Clinical Immunology Unit, Department of Medicine, University of Padova, 35128 Padova, Italy.
Alessandro SalvalaggioNeurology Unit, Department of Neurosciences, University of Padova, 35128 Padova, Italy.
Alessandra TedeschiASST Grande Ospedale Metropolitano Niguarda, Niguarda Cancer Center, 20162 Milano, Italy.
Livio TrentinHematology and Clinical Immunology Unit, Department of Medicine, University of Padova, 35128 Padova, Italy.ORCID 0000-0003-1222-6149
Chiara BrianiNeurology Unit, Department of Neurosciences, University of Padova, 35128 Padova, Italy.ORCID 0000-0001-8035-0200
University of Padua · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · IT

Funding

Italian Association for Cancer Research IG-25024Ricerca per Credere nella Vita RCV odv grant to LT
6 · The paper itself

Abstract

Monoclonal gammopathy and peripheral neuropathy are common diseases of elderly patients, and almost 10% of patients with neuropathy of unknown cause have paraprotein. However, growing evidence suggests that several hematological malignancies synthesize and release monoclonal proteins that damage the peripheral nervous system through different mechanisms. The spectrum of the disease varies from mild to rapidly progressive symptoms, sometimes affecting not only sensory nerve fibers, but also motor and autonomic fibers. Therefore, a multidisciplinary approach, mainly between hematologists and neurologists, is recommended in order to establish the correct diagnosis of monoclonal gammopathy of neurological significance and to tailor therapy based on specific genetic mutations. In this review, we summarize the spectrum of monoclonal gammopathies of neurological significance, their distinctive clinical and neurophysiological phenotypes, the most relevant pathophysiological events and new therapeutic approaches.

Indexed as

anti-myelin-associated-glycoprotein (MAG) polyneuropathyCastleman’s diseaseibrutinibmonoclonal gammopathies of neurological significance (MGNS)POEMS syndromerituximabvenetoclax

Identifiers

PMID35326711
PMCPMC8946535
OpenAlexW4221007594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.