ArticleCancers2022
Benchmarking Safety Indicators of Surgical Treatment of Brain Metastases Combined with Intraoperative Radiotherapy: Results of Prospective Observational Study with Comparative Matched-Pair Analysis.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebellar glioblastoma in adults: a comparative single-center matched pair analysis and systematic review of the literature.Journal of cancer research and clinical oncology · 2024Pooled it
- Prognostic Value of Perioperative Anemia in Neurosurgical-Oncological Treatment of Spinal Metastases.International journal of cancer · 2026Article
- Early versus delayed postoperative extubation after elective neurosurgical treatment of brain metastasis.Journal of cancer research and clinical oncology · 2025Article
- Intraoperative radiotherapy in brain metastasis surgery allows faster transition to systemic therapy.Neuro-oncology practice · 2025Article
- Bone mineral density as potential individual prognostic biomarker in patients with neurosurgically treated spinal metastasis.Journal of cancer research and clinical oncology · 2025Article
- Image Guided Intraoperative Radiation Therapy After Surgical Resection of Brain Metastases: A First In-Human Feasibility Report.Advances in radiation oncology · 2024Article
- Synchronous versus metachronous spinal metastasis: a comparative study of survival outcomes following neurosurgical treatment.Journal of cancer research and clinical oncology · 2024Article
- Outcome assessment of intraoperative radiotherapy for brain metastases: results of a prospective observational study with comparative matched-pair analysis.Journal of neuro-oncology · 2023Observational
- Opportunities and Alternatives of Modern Radiation Oncology and Surgery for the Management of Resectable Brain Metastases.Cancers · 2023Review
- Survival in patients with surgically treated brain metastases: does infratentorial location matter?Neurosurgical review · 2023Article
- Resection of supratentorial brain metastases with intraoperative radiotherapy. Is it safe? Analysis and experiences of a single center cohort.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intraoperative radiotherapy (IORT) of the operative cavity for surgically treated brain metastasis (BM) has gained increasing prominence with respect to improved local tumor control. However, IORT immediately performed at the time of surgery might be associated with increased levels of perioperative adverse events (PAEs). In the present study, we performed safety metric profiling in patients who had undergone surgery for BM with and without IORT in order to comparatively analyze feasibility of IORT as an adjuvant radiation approach. Between November 2020 and October 2021, 35 patients were surgically treated for BM with IORT at our neuro-oncological center. Perioperative complication profiles were collected in a prospective observational cohort study by means of patient safety indicators (PSIs), hospital-acquired conditions (HACs), and specific cranial-surgery-related complications (CSCs) as high-standard quality metric tools and compared to those of an institutional cohort of 388 patients with BM resection without IORT in a balanced comparative matched-pair analysis. Overall, 4 out of 35 patients (11%) with IORT in the course BM resection suffered from PAEs, accounting for 3 PSIs (9%) and 1 HAC (3%). Balanced matched-pair analysis did not reveal significant differences in the perioperative complication profiles between the cohorts of patients with and without IORT (
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