Evidence map›Paper›PMID 35326601›Full record

ArticleCancers2022

The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells.

Palak Sekhri, Debbie K Ledezma, Anshi Shukla, Elizabeth E Sweeney, Rohan Fernandes

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Neuroblastoma-A Review of Combination Immunotherapy.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Engineering Versatile Nanomedicines for Ultrasonic Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Palak SekhriGeorge Washington Cancer Center, Department of Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-8178-8562
Debbie K LedezmaGeorge Washington Cancer Center, Department of Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-7922-3773
Anshi ShuklaGeorge Washington Cancer Center, Department of Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC 20052, USA.
Elizabeth E SweeneyGeorge Washington Cancer Center, Department of Biochemistry & Molecular Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-7799-1576
Rohan FernandesGeorge Washington Cancer Center, Department of Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-9439-4626
George Washington University · US

Funding

Engineered Ensemble Nanoimmunotherapies for CancerR37CA226171 · NCI · GEORGE WASHINGTON UNIVERSITY · PI FERNANDES, ROHAN · 2019 to 2024
$2.6M
Alex's Lemonade Stand Foundation 'A' AwardGeorge Washington University Cancer Center FundsNCI NIH HHS R37 CA226171NCI NIH HHS R37CA226171
6 · The paper itself

Abstract

Photothermal therapy (PTT) is an effective method for tumor eradication and has been successfully combined with immunotherapy. However, besides its cytotoxic effects, little is known about the effect of the PTT thermal dose on the immunogenicity of treated tumor cells. Therefore, we administered a range of thermal doses using Prussian blue nanoparticle-based photothermal therapy (PBNP-PTT) and assessed their effects on tumor cell death and concomitant immunogenicity correlates in two human neuroblastoma cell lines: SH-SY5Y (

Indexed as

immunogenic cell deathimmunogenicityMYCN amplificationnanoimmunotherapyneuroblastomaphotothermal therapyPrussian blue nanoparticlesthermal dose

Identifiers

PMID35326601
PMCPMC8945975
OpenAlexW4220733699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.