Evidence map›Paper›PMID 35326499›Full record

ReviewCells2022

Transposable Elements: Major Players in Shaping Genomic and Evolutionary Patterns.

Nunzia Colonna Romano, Laura Fanti

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  5. Article
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  7. Article
  8. Comparative Genomics Reveals Host-Specific Adaptation ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Comparative Analysis of Chromosome Repeat DNA Patterns in FourInternational journal of molecular sciences · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nunzia Colonna RomanoIstituto Pasteur Italia, Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0587-5853
Laura FantiIstituto Pasteur Italia, Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0003-4380-997X
Istituto Pasteur · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transposable elements (TEs) are ubiquitous genetic elements, able to jump from one location of the genome to another, in all organisms. For this reason, on the one hand, TEs can induce deleterious mutations, causing dysfunction, disease and even lethality in individuals. On the other hand, TEs can increase genetic variability, making populations better equipped to respond adaptively to environmental change. To counteract the deleterious effects of TEs, organisms have evolved strategies to avoid their activation. However, their mobilization does occur. Usually, TEs are maintained silent through several mechanisms, but they can be reactivated during certain developmental windows. Moreover, TEs can become de-repressed because of drastic changes in the external environment. Here, we describe the 'double life' of TEs, being both 'parasites' and 'symbionts' of the genome. We also argue that the transposition of TEs contributes to two important evolutionary processes: the temporal dynamic of evolution and the induction of genetic variability. Finally, we discuss how the interplay between two TE-dependent phenomena, insertional mutagenesis and epigenetic plasticity, plays a role in the process of evolution.

Indexed as

DNA Transposable ElementsEvolution, MolecularGenomicsHumansMutagenesis, InsertionalDNA Transposable Elementsenvironmental stressepigeneticsevolutiontransposable elements

Identifiers

PMID35326499
PMCPMC8947103
OpenAlexW4220919680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.