ReviewCells2022
Interconnection between Cardiac Cachexia and Heart Failure-Protective Role of Cardiac Obesity.
Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Differences in peak oxygen uptake in heart failure patients with and without cachexia: A systematic review and meta-analysis.Physiological reports · 2025Pooled it
- Thbs1Journal of advanced research · 2026Article
- Malnutrition as a critical predictor of in-hospital outcomes and resource utilization in heart failure: a 6-year nationwide analysis.BMC cardiovascular disorders · 2026Article
- Diabetes-related differences in body composition and their prognostic value among patients with heart failure and preserved ejection fraction: a cardiac-MRI-based study.Cardiovascular diabetology · 2026Article
- Heart-Specific and Conditional Deletion of theCells · 2026Article
- Plasma HMGB1 as a Potential Biomarker Reflecting the Clinical Outcome in Chronic Heart Failure Patients.Journal of clinical medicine · 2026Article
- Oral health profiles and quality of life in men with andropause symptoms: a structural equation modeling and cluster analysis approach.Frontiers in oral health · 2026Article
- The Geriatric Nutritional Risk Index and its association with all-cause mortality in cancer patients with sepsis: a dual-center retrospective cohort study.Frontiers in nutrition · 2026Article
- Prognostic Value of In-Hospital Nutritional Status Improvement in Heart Failure: Insights From JROADHF-NEXT Registry.Global heart · 2026Article
- Circulating miRNAs Signature as a Predictor of Cachexia in Chronic Heart Failure: Diagnostic and Prognostic Implications.Journal of cardiovascular translational research · 2025Article
- GLP-1 Receptor Agonists in Heart Failure.Biomolecules · 2025Review
- Nutritional risk, frailty and functional status in elderly heart failure patients.ESC heart failure · 2025Article
- The obesity paradox revisited - influence on the results of percutaneous coronary interventions.AsiaIntervention · 2025Article
- Psoas Muscle Index Predicts Perioperative Mortality in Patients Undergoing LVAD Implantation.Muscles (Basel, Switzerland) · 2025Article
- Hidden Malnutrition in Overweight and Obese Individuals with Chronic Heart Failure: Insights from the Pro-HEART Trial.Nutrients · 2025Article
- Longitudinal Assessment of Body Composition and Inflammatory Status in Rheumatoid Arthritis During TNF Inhibitor Treatment: A Pilot Study.International journal of molecular sciences · 2025Observational
- Beyond the Scale: The Hidden Burden of Underweight and Cachexia in Adults with Congenital Heart Defects and Heart Failure-Results from the Pathfinder CHD-Registry.Journal of clinical medicine · 2025Article
- Iron Deficiency Treatment in Heart Failure-Challenges and Therapeutic Solutions.Journal of clinical medicine · 2025Review
- Tracking Pathways Linking Obesity with Heart Failure.Nutrients · 2025Review
- Partial obesity paradox regarding mortality in patients hospitalized with diastolic or systolic heart failure.Future cardiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cachexia may be caused by congestive heart failure, and it is then called cardiac cachexia, which leads to increased morbidity and mortality. Cardiac cachexia also worsens skeletal muscle degradation. Cardiac cachexia is the loss of edema-free muscle mass with or without affecting fat tissue. It is mainly caused by a loss of balance between protein synthesis and degradation, or it may result from intestinal malabsorption. The loss of balance in protein synthesis and degradation may be the consequence of altered endocrine mediators such as insulin, insulin-like growth factor 1, leptin, ghrelin, melanocortin, growth hormone and neuropeptide Y. In contrast to many other health problems, fat accumulation in the heart is protective in this condition. Fat in the heart can be divided into epicardial, myocardial and cardiac steatosis. In this review, we describe and discuss these topics, pointing out the interconnection between heart failure and cardiac cachexia and the protective role of cardiac obesity. We also set the basis for possible screening methods that may allow for a timely diagnosis of cardiac cachexia, since there is still no cure for this condition. Several therapeutic procedures are discussed including exercise, nutritional proposals, myostatin antibodies, ghrelin, anabolic steroids, anti-inflammatory substances, beta-adrenergic agonists, medroxyprogesterone acetate, megestrol acetate, cannabinoids, statins, thalidomide, proteasome inhibitors and pentoxifylline. However, to this date, there is no cure for cachexia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.