Evidence map›Paper›PMID 35326483›Full record

ArticleCells2022

Ciliated (FOXJ1

Sofia C Wijk, Pavan Prabhala, Anna Löfdahl, Annika Nybom, Stefan Lang, Hans Brunnström, Leif Bjermer, Gunilla Westergren-Thorsson, Mattias Magnusson

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sofia C WijkDivision of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 223 62 Lund, Sweden.
Pavan PrabhalaDivision of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 223 62 Lund, Sweden.
Anna LöfdahlDivision of Lung Biology, Department of Experimental Medical Science, Lund University, 223 62 Lund, Sweden.
Annika NybomDivision of Lung Biology, Department of Experimental Medical Science, Lund University, 223 62 Lund, Sweden.
Stefan LangDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, 223 62 Lund, Sweden.ORCID 0000-0002-0854-2328
Hans BrunnströmDepartment of Clinical Sciences, Lund University, 223 62 Lund, Sweden.ORCID 0000-0001-7402-138X
Leif BjermerDivision of Respiratory Medicine and Allergology, Department of Clinical Sciences, Lund University, 223 62 Lund, Sweden.
Gunilla Westergren-ThorssonDivision of Lung Biology, Department of Experimental Medical Science, Lund University, 223 62 Lund, Sweden.ORCID 0000-0001-5327-8805
Mattias MagnussonDivision of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 223 62 Lund, Sweden.
Lund University · SE

Funding

Swedish Cancer Society 20 1326 PjFSwedish Foundation for Strategic Research SBE13/0130Swedish Heart-Lung Foundation 2021/0340, 2018/0171, 2020/0651, 2021/0289Swedish Research Council 2020/01375
6 · The paper itself

Abstract

Cell-based therapies hold great promise in re-establishing organ function for many diseases, including untreatable lung diseases such as idiopathic pulmonary fibrosis (IPF). However, many hurdles still remain, in part due to our lack of knowledge about the disease-driving mechanisms that may affect the cellular niche and thereby possibly hinder the function of any transplanted cells by imposing the disease phenotype onto the newly generated progeny. Recent findings have demonstrated increased ciliation of lung cells from IPF patients, but how this affects ciliated cell function and the airway milieu is not well-known. Here, we performed single-cell RNA sequencing on primary ciliated (FOXJ1

Indexed as

Idiopathic Pulmonary FibrosisApoferritinsForkhead Transcription FactorsGene Expression ProfilingHumansLungSignal TransductionApoferritinsForkhead Transcription FactorsFOXJ1 protein, humanbasal cellsciliated cellsferritin light chainimmunofluorescenceIPFsingle-cell RNA sequencingstem cell therapy

Identifiers

PMID35326483
PMCPMC8947470
OpenAlexW4220976238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.