SynthesisCells2022
Central Auditory Functions of Alzheimer's Disease and Its Preclinical Stages: A Systematic Review and Meta-Analysis.
Synthesis in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06495268 (Healthy Hearing for Healthy Ageing), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Healthy Hearing for Healthy Ageing: a Proof-of-concept Randomized Controlled Trial of Data-driven Hearing Rehabilitation Versus Standard Care in Older Adults With Hearing Impairment.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Alzheimer's early detection in post-acute COVID-19 syndrome: a systematic review and expert consensus on preclinical assessments.Frontiers in aging neuroscience · 2023Pooled it
- Comorbidities and health-care use prior to early-onset Alzheimer's disease: A population-based case-control study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Unmasking preclinical Alzheimer's pathology: auditory distraction cost and occupational reserve jointly discriminate amyloid positivity in subjective cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Hearing Loss as a Potentially Modifiable Marker of Dementia Risk: Neurological Evidence, Uncertainty, and Clinical Interpretation.Neuro-degenerative diseases · 2026Review
- Oropharyngeal dysphagia and amyloid beta pathology in the TgF344-AD rat model of Alzheimer's disease.Frontiers in behavioral neuroscience · 2026Article
- Parallel multilink group joint ICA (pmg-jICA): Fusion of 3D structural and 4D functional data across multiple resting fMRI networks.Network neuroscience (Cambridge, Mass.) · 2026Article
- Auditory processing and its cognitive correlates in older adults with mild cognitive impairment.BMC geriatrics · 2025Article
- Hearing impairment and dementia: cause, catalyst or consequence?Journal of neurology · 2025Review
- The Auditory Brainstem Response Diagnoses Alzheimer-Like Disease in the 5xFAD Mouse Model.eNeuro · 2025Article
- Efficacy of acoustic stimulation techniques on cognitive functions in individuals with Alzheimer's disease-a scoping review.Alzheimer's research & therapy · 2024Article
- An In Silico Study Based on QSAR and Molecular Docking and Molecular Dynamics Simulation for the Discovery of Novel Potent Inhibitor against AChE.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Hearing Loss and Cognitive Decline in the Aging Population: Emerging Perspectives in Audiology.Audiology research · 2024Article
- Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction:Advances in pharmacological and pharmaceutical sciences · 2024Article
- Article
- Comprehension of acoustically degraded speech in Alzheimer's disease and primary progressive aphasia.Brain : a journal of neurology · 2023Article
- Association of Central Auditory Processing Dysfunction With Preclinical Alzheimer's Disease.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2023Observational
- Listening with an Ageing Brain - a Cognitive Challenge.Laryngo- rhino- otologie · 2023Review
- Clinical Assessment Tools for the Detection of Cognitive Impairment and Hearing Loss in the Ageing Population: A Scoping Review.Clinical interventions in aging · 2023Article
- Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology.EBioMedicine · 2022Article
- Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2020, 55 million people worldwide were living with dementia, and this number is projected to reach 139 million in 2050. However, approximately 75% of people living with dementia have not received a formal diagnosis. Hence, they do not have access to treatment and care. Without effective treatment in the foreseeable future, it is essential to focus on modifiable risk factors and early intervention. Central auditory processing is impaired in people diagnosed with Alzheimer's disease (AD) and its preclinical stages and may manifest many years before clinical diagnosis. This study systematically reviewed central auditory processing function in AD and its preclinical stages using behavioural central auditory processing tests. Eleven studies met the full inclusion criteria, and seven were included in the meta-analyses. The results revealed that those with mild cognitive impairment perform significantly worse than healthy controls within channel adaptive tests of temporal response (ATTR), time-compressed speech test (TCS), Dichotic Digits Test (DDT), Dichotic Sentence Identification (DSI), Speech in Noise (SPIN), and Synthetic Sentence Identification-Ipsilateral Competing Message (SSI-ICM) central auditory processing tests. In addition, this analysis indicates that participants with AD performed significantly worse than healthy controls in DDT, DSI, and SSI-ICM tasks. Clinical implications are discussed in detail.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.