ArticleBrain sciences2022
Changes in Hippocampus and Amygdala Volume with Hypoxic Stress Related to Cardiorespiratory Fitness under a High-Altitude Environment.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06985797 (Effects of Funfitness Program With Music Tempo on Perceived Exertion, Flexibility, Balance and Cognition in Gym Going Females), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Funfitness Program With Music Tempo on Perceived Exertion, Flexibility, Balance and Cognition in Gym Going Females
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Chronic hypoxia reshapes the brain: subregional volume reductions of the hippocampus and amygdala contrasts with behavioral resilience in long-term high-altitude migrants.Frontiers in neuroscience · 2026Article
- Hypoxia's Impact on Hippocampal Functional Connectivity: Insights from Resting-State fMRI Studies.Brain sciences · 2025Review
- Association of sugar-sweetened beverage consumption and cardiorespiratory fitness with executive function: a cross-sectional survey based on Tajik adolescents at high altitude in China.Frontiers in public health · 2025Article
- A healthy mind in a healthy body: Effects of arteriosclerosis and other risk factors on cognitive aging and dementia.The psychology of learning and motivation · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The morphology of the hippocampus and amygdala can be significantly affected by a long-term hypoxia-induced inflammatory response. Cardiorespiratory fitness (CRF) has a significant effect on the neuroplasticity of the hippocampus and amygdala by countering inflammation. However, the role of CRF is still largely unclear at high altitudes. Here, we investigated brain limbic volumes in participants who had experienced long-term hypoxia exposure in Tibet (3680 m), utilizing high-resolution structural images to allow the segmentation of the hippocampus and amygdala into their constituent substructures. We recruited a total of 48 participants (48 males; aged = 20.92 ± 1.03 years) to undergo a structural 3T MRI, and the levels of maximal oxygen uptake (VO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.