Evidence map›Paper›PMID 35326308›Full record

ArticleBrain sciences2022

Substance Abuse in Emerging Adults: The Role of Neuromelanin and Ventral Striatal Response to Social and Monetary Rewards.

Johanna M Jarcho, James B Wyngaarden, Camille R Johnston, Megan Quarmley, David V Smith, Clifford M Cassidy

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Johanna M JarchoDepartment of Psychology, Temple University, Philadelphia, PA 19122, USA.
James B WyngaardenDepartment of Psychology, Temple University, Philadelphia, PA 19122, USA.
Camille R JohnstonDepartment of Psychology, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0001-9217-8647
Megan QuarmleyDepartment of Psychology, Temple University, Philadelphia, PA 19122, USA.
David V SmithDepartment of Psychology, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0001-5754-9633
Clifford M CassidyUniversity of Ottawa Institute of Mental Health Research, Affiliated with The Royal, Ottawa, ON K1Z 8N3, Canada.
Temple University · USUniversity of Ottawa · CA

Funding

ProNET: Psychosis-Risk Outcomes NetworkU01MH124639 · NIMH · YALE UNIVERSITY · PI CARRIE E BEARDEN, JOHN M KANE · 2020 to 2026
$81.2M
Social Reward Processing Across the Lifespan: Identifying Risk Factors for Financial ExploitationRF1AG067011 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI SMITH, DAVID VICTOR · 2021 to 2021
$2.0M
Aberrant Reward Sensitivity: Mechanisms Underlying Substance UseR03DA046733 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI SMITH, DAVID VICTOR · 2019 to 2019
$229k
Neural Mechanisms of Social Rejection elicited Aggression in AdolescenceF31MH125478 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI QUARMLEY, MEGAN · 2021 to 2022
$61k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R21-HD093912NIA NIH HHS RF1-AG067011NIDA NIH HHS R03-DA046733NIMH NIH HHS F31-MH125478NIMH NIH HHS R01-MH12385NIMH NIH HHS U01-MH124639Temple University Public Policy Lab FellowshipTemple University TUBRIC Neurospark Trainee Award
6 · The paper itself

Abstract

Perturbations in dopamine system function may increase risk of substance use disorder (SUD). We recently demonstrated that neuromelanin (NM) MRI signal in the substantia nigra, a non-invasive index of dopamine system function, is elevated in long term cocaine users (Cassidy et al., 2020). However, it is unclear whether elevated NM-MRI signal is linked to risk of SUD, or is a byproduct of long-term drug use. Our prior work failed to show relations between NM-MRI signal and functional engagement of ventral striatum during a monetary reward task. However, social experiences are commonly linked to drug use and relapse. Given that, NM-MRI signal may be more closely linked to ventral striatal engagement during social, rather than monetary reward processing. Emerging adults (

Indexed as

adolescent SUDfMRImidbrainNM-MRIpeer feedbackrisk factors

Identifiers

PMID35326308
PMCPMC8946041
OpenAlexW4221061856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.