ReviewBrain sciences2022
Pain in Persons with Disorders of Consciousness.
Review in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Manual Dexterity in Patients with Disorder of Consciousness.Archives of rehabilitation research and clinical translation · 2026Article
- The effect of educational intervention using behavioral pain scale to diagnose pain and relief care in patients admitted to the intensive care unit.Journal of education and health promotion · 2026Article
- Do some people with a prolonged disorder of consciousness experience pain? A clinically focused narrative review and synthesis.Clinical rehabilitation · 2025Review
- Evaluation of pressure-induced pain in patients with disorders of consciousness based on functional near infrared spectroscopy.Frontiers in neurology · 2025Article
- Nociception Coma Scale-Revised with Personalized Painful Stimulus Versus Standard Stimulation in Persons with Disorders of Consciousness: An International Multicenter Study.Journal of clinical medicine · 2024Article
- Disorders of Consciousness Rehabilitation: Ethical Dimensions and Epistemic Dilemmas.Physical medicine and rehabilitation clinics of North America · 2024Review
- Analgesia for the Bayesian Brain: How Predictive Coding Offers Insights Into the Subjectivity of Pain.Current pain and headache reports · 2023Review
- Comparing indices of responsiveness for the Coma Near-Coma Scale with and without pain items: An Exploratory study.Brain and behavior · 2023Observational
- Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review.Frontiers in systems neuroscience · 2023Review
- The Consciousness of Pain: A Thalamocortical Perspective.NeuroSci · 2022Article
- Pain assessment during physiotherapy and noxious stimuli in patients with disorders of consciousness: A preliminary study.Frontiers in integrative neuroscience · 2022Article
- Pain perception and attitudes toward life-sustaining treatment in pediatric patients with disorders of consciousness: a survey of Chinese healthcare professionals.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain and suffering in persons with disorders of consciousness (DoC) remain poorly understood, frequently unaddressed or inadequately addressed, and controversial on numerous levels. This narrative literature review will address a number of critical issues germane to pain and suffering in this challenging group of patients, providing an introductory overview of the topic, perspectives on current knowledge regarding pain pathoanatomy and pathophysiology, and a review of common pain generators and factors that can lead to the chronifcation of pain. Caveats on bedside pain assessment challenges, as well as electrophysiologic and neuroimaging findings in these patients, will also be explored. Pain management techniques, including non-pharmacological and pharmacological, will be reviewed. Ethical considerations in the context of pain and suffering in persons with disorders of consciousness will round out the review prior to our concluding comments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.