ReviewAntioxidants (Basel, Switzerland)2022
Metabolic Basis and Clinical Evidence for Skin Lightening Effects of Thiol Compounds.
Review in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Oral administration of cysteine peptides attenuates UV-B-induced skin erythema and pigmentation in humans.Scientific reports · 2024Trial
- Phenylalanine Butyramide: A Butyrate Derivative as a Novel Inhibitor of Tyrosinase.International journal of molecular sciences · 2024Trial
- Biochemical Changes and Molecular Mechanisms Mediated by Sulfur Dioxide in Healthy Skin and Dermatological Disorders.Biomolecules · 2026Review
- Therapeutic Potential of Cysteine and Its Derivatives in Dermatology.Molecules (Basel, Switzerland) · 2026Review
- Exploring Speckle Change Genes ofBiology · 2026Article
- The anti-aging potential of VA'S new derivatives through metabolomic profiling.Scientific reports · 2025Article
- Study on the synthesis and biological activity assessment of kojic acid sulfide schiff base.Scientific reports · 2025Article
- TBP-based AIE Fluorescent Probe for Cysteine/Homocysteine Detection and Imaging in Living Cells.Journal of fluorescence · 2025Article
- Platelet-rich plasma-derived exosomes stimulate hair follicle growth through activation of the Wnt/β-Catenin signaling pathway.Regenerative therapy · 2025Article
- Inhibition of Tyrosinase and Melanogenesis by Carboxylic Acids: Mechanistic Insights and Safety Evaluation.Molecules (Basel, Switzerland) · 2025Article
- Research progress on peptides that inhibit melanin synthesis.Frontiers in pharmacology · 2025Review
- Exploring the Safety and Efficacy of Glutathione Supplementation for Skin Lightening: A Narrative Review.Cureus · 2025Review
- Skin proteomic screening and functional analysis of differential proteins associated with coat color in sheep (Ovis aries).Animal bioscience · 2024Article
- Skin Color Analysis of Various Body Parts (Forearm, Upper Arm, Elbow, Knee, and Shin) and Changes with Age in 53 Korean Women, Considering Intrinsic and Extrinsic Factors.Journal of clinical medicine · 2024Article
- Multifaceted Effects of L-Cysteine, L-Ascorbic Acid, and Their Derivatives on the Viability and Melanin Synthesis of B16/F10 Cells under Different Conditions.Antioxidants (Basel, Switzerland) · 2024Article
- Advances of curcumin in nervous system diseases: the effect of regulating oxidative stress and clinical studies.Frontiers in pharmacology · 2024Review
- Hydroxypropyl-β-Cyclodextrin-BasedAntioxidants (Basel, Switzerland) · 2023Article
- Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies.Antioxidants (Basel, Switzerland) · 2022Review
- Exosomes based advancements for application in medical aesthetics.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Melanin pigment is a major factor in determining the color of the skin, and its abnormal increase or decrease can cause serious pigmentation disorders. The melanin pigment of the skin is divided into light pheomelanin and dark eumelanin, and a big difference between them is whether they contain sulfur. Melanin synthesis starts from a common reaction in which tyrosine or dihydroxyphenylalanine (DOPA) is oxidized by tyrosinase (TYR) to produce dopaquinone (DQ). DQ is spontaneously converted to leukodopachrome and then oxidized to dopachrome, which enters the eumelanin synthesis pathway. When DQ reacts with cysteine, cysteinyl dopa is generated, which is oxidized to cysteinyl DQ and enters the pheomelanin synthesis pathway. Therefore, thiol compounds can influence the relative synthesis of eumelanin and pheomelanin. In addition, thiol compounds can inhibit enzymatic activity by binding to copper ions at the active site of TYR, and act as an antioxidant scavenging reactive oxygen species and free radicals or as a modulator of redox balance, thereby inhibiting overall melanin synthesis. This review will cover the metabolic aspects of thiol compounds, the role of thiol compounds in melanin synthesis, comparison of the antimelanogenic effects of various thiol compounds, and clinical trials on the skin lightening efficacy of thiol compounds. We hope that this review will help identify the advantages and disadvantages of various thiol compounds as modulators of skin pigmentation and contribute to the development of safer and more effective strategies for the treatment of pigmentation disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.