Evidence map›Paper›PMID 35326098›Full record

ArticleAntioxidants (Basel, Switzerland)2022

The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and

Aline Boveto Santamarina, Ruan Carlos Macêdo Moraes, Victor Nehmi Filho, Gilson Masahiro Murata, Jéssica Alves de Freitas, Danielle Araujo de Miranda, Anderson Romério Azevedo Cerqueira, Soraia Katia Pereira Costa, Ana Flávia Fernandes Ferreira, Luiz Roberto Britto and 5 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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  4. Antidiabetic Potential ofMolecules (Basel, Switzerland) · 2026
    Article
  5. Article
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  7. Effect of alpha-lipoic acid andWorld journal of hepatology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Aline Boveto SantamarinaDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Santos 11015-020, SP, Brazil.
Ruan Carlos Macêdo MoraesNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, Brazil.ORCID 0000-0002-0178-8480
Victor Nehmi FilhoNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, Brazil.
Gilson Masahiro MurataLaboratory of Medical Investigation (LIM-29), Clinic Medical Department, University of São Paulo Medical School, São Paulo 01246-903, SP, Brazil.
Jéssica Alves de FreitasNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, Brazil.ORCID 0000-0002-9457-4587
Danielle Araujo de MirandaDepartment of Physiology, Escola Paulista de Medicina/Universidade Federal de São Paulo, São Paulo 04023-062, SP, Brazil.
Anderson Romério Azevedo CerqueiraDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, SP, Brazil.ORCID 0000-0001-7057-2563
Soraia Katia Pereira CostaDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, SP, Brazil.ORCID 0000-0002-2574-4490
Ana Flávia Fernandes FerreiraDepartamento de Fisiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, SP, Brazil.
Luiz Roberto BrittoDepartamento de Fisiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, SP, Brazil.
Juliana Alves de CamargoLaboratory of Medical Investigation (LIM-55), Urology Department, University of São Paulo Medical School, São Paulo 01246-903, SP, Brazil.
Daniela Rodrigues de OliveiraNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, Brazil.ORCID 0000-0003-0579-7234
Flavia Neto de JesusDepartment of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine Alberta, Calgary, AB T2N 1N4, Canada.
José Pinhata OtochNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, Brazil.
Ana Flávia Marçal PessoaNatural Products and Derivatives Laboratory (LIM-26), Department of Surgery, University of São Paulo Medical School, São Paulo 01246-903, SP, Brazil.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BR

Funding

Efeom Nutrition S.A. 01/04-21National Council for Scientific and Technological Development #312514/2019-0Royal Society of Medicine 2016/R1 Newton Grant-eGAP SZ50730
6 · The paper itself

Abstract

The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following groups: high-fat diet (HFD) vehicle, HFD + Supplemented, HFD + Supplemented_S, and isolated compounds. The vehicle and experimental formulations were administered orally by gavage once a day over the four weeks of the diet (28 consecutive days). We evaluated the energy homeostasis, cytokines, and mitochondrial gene expression in these groups of mice. After four weeks of supplementation, only the new nutraceutical group (HFD + Supplemented) experienced reduced fasting glycemia, insulin, HOMA index, HOMA-β, dyslipidemia, ectopic fat deposition, and hepatic fibrosis levels. Additionally, the PPARγ coactivator 1 α (

Indexed as

antioxidant enzymesInterleukin-6mineralsnutraceuticalobesityPgc-1αprebioticsilymarintype-2 diabetesyeast β-glucan

Identifiers

PMID35326098
PMCPMC8944780
OpenAlexW4213425056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.