Evidence map›Paper›PMID 35326013›Full record

ArticleIndian journal of ophthalmology2022

Comparative study on costs incurred for treatment of patients with bacterial and fungal keratitis - A retrospective analysis.

Naveen Radhakrishnan, Neha Pathak, Krishnan Raja Subramanian, Daisy Rani Das, Reagan Ningombam, Isha Khaitan, Neha Gandhi, Ramesh Rahul, N Venkatesh Prajna

Open access · diamondAbstract read
In one paragraph

Article in Indian journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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  10. Commentary: Tackling the "silent epidemic".Indian journal of ophthalmology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Naveen RadhakrishnanDepartment of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Neha PathakDepartment of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Krishnan Raja SubramanianDepartment of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Daisy Rani DasDepartment of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Reagan NingombamDepartment of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Isha KhaitanDepartment of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Neha GandhiDepartment of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Ramesh RahulDepartment of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
N Venkatesh PrajnaDepartment of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Aravind Eye Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To compare the costs associated with medications and travel of patients with smear-proven bacterial keratitis and fungal keratitis in a tertiary care center in India. Methods: Retrospective analysis of case records of a cohort of patients who presented between April 2017 and March 2018 to a tertiary care center in India, with infectious keratitis who were smear-positive for bacteria or fungi, and whose costs of treatment and travel were supported by a philanthropic program. Results: In total, 672 case records of 177 smear-positive bacterial keratitis (BK) and 495 smear-positive fungal keratitis (FK) were included in the study. Further, 62% of BK and 75% of FK received more than one antimicrobial drug (P < 0.001). The mean total medication cost (INR) was significantly more in FK (959.1 ± 675.2) compared to BK (674.9 ± 463.7) (P < 0.0001). The mean medication cost (INR) per visit was also more for FK (201.1 ± 109.4) compared to BK (155.2 ± 84.1) (P < 0.0001). The mean total medication cost was significantly more for FK for both patients who healed with medical treatment (611.6 ± 395.6 for BK, 801.5 ± 599.9 for FK, P = 0.0005) and for patients who required TPK (953.7 ± 653.1 for BK, 1374.6 ± 701.5 for FK, P = 0.0023) compared to their respective counterparts in BK. Conclusion: Patients with fungal keratitis incurred significantly more on medications compared to patients with bacterial keratitis irrespective of whether they had healed with successful medical treatment or required therapeutic keratoplasty. Prolonged duration of treatment and the high costs of antifungal medications account for the significant economic burden of fungal keratitis.

Indexed as

Corneal UlcerEye Infections, BacterialEye Infections, FungalKeratitisBacteriaHumansRetrospective StudiesAntibacterial medicationsantifungal medicationsaspergillus keratitisbacterial keratitiscosts of treatmentfungal keratitisfusarium keratitis

Identifiers

PMID35326013
PMCPMC9240582
OpenAlexW4220844497

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.