Evidence map›Paper›PMID 35325813›Full record

ArticleNeurobiology of aging2022

Cerebrovascular reactivity deficits in cognitively unimpaired older adults: vasodilatory versus vasoconstrictive responses.

Belinda Yew, Jung Yun Jang, Shubir Dutt, Yanrong Li, Isabel J Sible, Aimée Gaubert, Jean K Ho, Anna E Blanken, Anisa Marshall, Xingfeng Shao and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Belinda YewDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Jung Yun JangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Shubir DuttDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Yanrong LiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Isabel J SibleDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Aimée GaubertInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Jean K HoInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Anna E BlankenDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Anisa MarshallDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Xingfeng ShaoStevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Danny J J WangStevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Daniel A NationInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA; Department of Psychological Science, University of California, Irvine, Irvine, CA, USA. Electronic address: dnation@uci.edu.
University of Southern California · USUniversity of California, Irvine · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS P01 AG052350NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228
6 · The paper itself

Abstract

Cerebrovascular reactivity (CVR) deficits may index vulnerability to vascular brain injury and cognitive impairment, but findings on age-related changes in CVR have been mixed, and no studies to date have directly compared age-related changes in CVR to hypercapnia versus hypocapnia. The present study compared CVR in 31 cognitively unimpaired older adults (ages 55-87) and 30 healthy younger adults (ages 18-28). Breath control tasks induced CVR to hypocapnia (0.1 Hz paced breathing) and hypercapnia (15s breath holds) during pseudo-continuous arterial spin labeling MRI. Relative to younger adults, cognitively unimpaired older adults displayed lower levels of global CVR under both hypocapnia and hypercapnia. In region-of-interest analyses, older adults exhibited attenuated CVR to hypocapnia in select frontal and temporal regions, and lower CVR to hypercapnia in all cortical, limbic, and subcortical regions examined, relative to younger adults. Results indicate age-related deficits in CVR are detectible even in cognitively unimpaired older adults and are disproportionately related to vasodilatory (hypercapnia) responses relative to vasoconstrictive (hypocapnia) responses. Findings may offer means for early detection of cerebrovascular dysfunction.

Indexed as

Cognitive DysfunctionHypocapniaAgedAged, 80 and overCerebrovascular CirculationHumansHypercapniaMagnetic Resonance ImagingCerebral blood flowCerebrovascular reactivityCerebrovascular reserveHypercapniaHypocapniaOlder adults

Identifiers

PMID35325813
PMCPMC10958374
OpenAlexW4213200130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.