Evidence map›Paper›PMID 35325627›Full record

Trial reportThe Lancet. Public health2022

Effect of a physical activity and behaviour maintenance programme on functional mobility decline in older adults: the REACT (Retirement in Action) randomised controlled trial.

Afroditi Stathi, Colin J Greaves, Janice L Thompson, Janet Withall, Peter Ladlow, Gordon Taylor, Antonieta Medina-Lara, Tristan Snowsill, Selena Gray, Colin Green and 13 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Lancet. Public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
33.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 2 countries.

Afroditi StathiSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. Electronic address: a.stathi@bham.ac.uk.
Colin J GreavesSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Janice L ThompsonSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Janet WithallSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK; Department for Health, University of Bath, Bath, UK.
Peter LadlowAcademic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, UK.
Gordon TaylorCollege of Medicine and Health, University of Exeter, Exeter, UK.
Antonieta Medina-LaraCollege of Medicine and Health, University of Exeter, Exeter, UK.
Tristan SnowsillCollege of Medicine and Health, University of Exeter, Exeter, UK.
Selena GrayFaculty of Health and Applied Sciences, University of the West of England (UWE) Bristol, Bristol, UK.
Colin GreenCollege of Medicine and Health, University of Exeter, Exeter, UK.
Heidi Johansen-BergOxford Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Claire E SextonOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK; Global Brain Health Institute, Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
James L J BilzonDepartment for Health, University of Bath, Bath, UK.
Jolanthe deKoningDepartment for Health, University of Bath, Bath, UK.
Jessica C BollenCollege of Medicine and Health, University of Exeter, Exeter, UK.
Sarah J MoorlockBirmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Max J WesternDepartment for Health, University of Bath, Bath, UK.
Naiara DemnitzDanish Research Centre for Magnetic Resonance, Centre for Functional Diagnostic Imaging and Research, Copenhagen University Hospital -Amager and Hvidovre, Hvidovre, Denmark.
Poppy SeagerOxford Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Jack M GuralnikDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
W Jack RejeskiDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA.
Melvyn HillsdonCollege of Life and Environmental Sciences, University of Exeter, Exeter, UK.
Kenneth R FoxCentre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.
University of Exeter · GBUniversity of Bath · GBUniversity of Birmingham · GBCancer Research UK Clinical Trials Unit · GBJohn Radcliffe Hospital · GBUniversity of Bristol · GBUniversity of Maryland, Baltimore · USUniversity of Oxford · GBUniversity of the West of England · GBWake Forest University · US

Funding

Wellcome Trust 110027/Z/15/Z
6 · The paper itself

Abstract

backgroundMobility limitations in old age can greatly reduce quality of life, generate substantial health and social care costs, and increase mortality. Through the Retirement in Action (REACT) trial, we aimed to establish whether a community-based active ageing intervention could prevent decline in lower limb physical functioning in older adults already at increased risk of mobility limitation.

methodsIn this pragmatic, multicentre, two-arm, single-blind, parallel-group, randomised, controlled trial, we recruited older adults (aged 65 years or older and who are not in full-time employment) with reduced lower limb physical functioning (Short Physical Performance Battery [SPPB] score 4-9) from 35 primary care practices across three sites (Bristol and Bath; Birmingham; and Devon) in England. Participants were randomly assigned to receive brief advice (three healthy ageing education sessions) or a 12-month, group-based, multimodal physical activity (64 1-h exercise sessions) and behavioural maintenance (21 45-min sessions) programme delivered by charity and community or leisure centre staff in local communities. Randomisation was stratified by site and adopted a minimisation approach to balance groups by age, sex, and SPPB score, using a centralised, online, randomisation algorithm. Researchers involved in data collection and analysis were masked but participants were not because of the nature of the intervention. The primary outcome was change in SPPB score at 24 months, analysed by intention to treat. This trial is registered with ISRCTN, ISRCTN45627165.

findingsBetween June 20, 2016, and Oct 30, 2017, 777 participants (mean age 77·6 [SD 6·8] years; 66% female; mean SPPB score 7·37 [1·56]) were randomly assigned to the intervention (n=410) and control (n=367) groups. Primary outcome data at 24 months were provided by 628 (81%) participants (294 in the control group and 334 in the intervention group). At the 24-month follow-up, the SPPB score (adjusted for baseline SPPB score, age, sex, study site, and exercise group) was significantly greater in the intervention group (mean 8·08 [SD 2·87]) than in the control group (mean 7·59 [2·61]), with an adjusted mean difference of 0·49 (95% CI 0·06-0·92; p=0·014), which is just below our predefined clinically meaningful difference of 0·50. One adverse event was related to the intervention; the most common unrelated adverse events were heart conditions, strokes, and falls.

interpretationFor older adults at risk of mobility limitations, the REACT intervention showed that a 12-month physical activity and behavioural maintenance programme could help prevent decline in physical function over a 24-month period.

fundingNational Institute for Health Research Public Health Research Programme (13/164/51).

Indexed as

Quality of LifeRetirementAgedExerciseFemaleHumansMaleMobility LimitationSingle-Blind Method

Identifiers

PMID35325627
PMCPMC8967718
OpenAlexW4220910884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.