Evidence map›Paper›PMID 35325497›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Euglenatides, Potent Antiproliferative Cyclic Peptides Isolated from the Freshwater Photosynthetic Microalga Euglena gracilis.

Mohammed Aldholmi, Rizwan Ahmad, Daniel Carretero-Molina, Ignacio Pérez-Victoria, Jesús Martín, Fernando Reyes, Olga Genilloud, Léa Gourbeyre, Thierry Gefflaut, Hanne Carlsson and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Why Euglenozoans.Methods in molecular biology (Clifton, N.J.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Mohammed AldholmiNatural Products and Alternative Medicine, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.ORCID 0000-0003-3270-0338
Rizwan AhmadNatural Products and Alternative Medicine, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.ORCID 0000-0001-6490-8219
Daniel Carretero-MolinaFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 34, 18016, Armilla, Granada, Spain.ORCID 0000-0003-4481-8157
Ignacio Pérez-VictoriaFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 34, 18016, Armilla, Granada, Spain.ORCID 0000-0002-4556-688X
Jesús MartínFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 34, 18016, Armilla, Granada, Spain.ORCID 0000-0001-7487-2790
Fernando ReyesFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 34, 18016, Armilla, Granada, Spain.ORCID 0000-0003-1607-5106
Olga GenilloudFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 34, 18016, Armilla, Granada, Spain.ORCID 0000-0002-4202-1219
Léa GourbeyreUniversité Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut Pascal, 63000, Clermont-Ferrand, France.
Thierry GefflautUniversité Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut Pascal, 63000, Clermont-Ferrand, France.ORCID 0000-0002-4411-8233
Hanne CarlssonSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.ORCID 0000-0002-3001-8258
Alexei MaklakovSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.ORCID 0000-0002-5809-1203
Ellis O'NeillSchool of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK.
Robert A FieldManchester Institute of Biotechnology, University of Manchester, Manchester, M1 7DN, UK.ORCID 0000-0001-8574-0275
Barrie WilkinsonJohn Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.ORCID 0000-0001-7646-7174
Maria O'ConnellSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.ORCID 0000-0002-0267-0951
A GanesanSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.ORCID 0000-0003-4862-7999
Fundación Medina · ESUniversity of East Anglia · GBCentre National de la Recherche Scientifique · FRImam Abdulrahman Bin Faisal University · SAJohn Innes Centre · GBUniversity of Manchester · GBUniversity of Nottingham · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/J/000C0618Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9790
6 · The paper itself

Abstract

By limiting the nitrogen source to glutamic acid, we isolated cyclic peptides from Euglena gracilis containing asparagine and non-proteinogenic amino acids. Structure elucidation was accomplished through spectroscopic methods, mass spectrometry and chemical degradation. The euglenatides potently inhibit pathogenic fungi and cancer cell lines e.g., euglenatide B exhibiting IC

Indexed as

Euglena gracilisMicroalgaeAnimalsCaenorhabditis elegansFresh WaterPeptides, CyclicPeptides, CyclicAntiproliferativeCyclic PeptidesMicroalgaeNatural ProductsNematodes

Identifiers

PMID35325497
PMCPMC9321709
OpenAlexW4220691772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.