Evidence map›Paper›PMID 35325473›Full record

ReviewCA: a cancer journal for clinicians2022

Cancer risk among World Trade Center rescue and recovery workers: A review.

Paolo Boffetta, Charles B Hall, Andrew C Todd, David G Goldfarb, Maria J Schymura, Jiehui Li, James E Cone, Rachel Zeig-Owens

Open access · diamondAbstract readReview
In one paragraph

Review in CA: a cancer journal for clinicians, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  8. Review
  9. Review
  10. Review
  11. Review
  12. Mutagenicity of the organic fraction of World Trade Center dust.Environmental and molecular mutagenesis · 2023
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Paolo BoffettaStony Brook Cancer Center, Stony Brook University, Stony Brook, New York.ORCID 0000-0002-3811-2791
Charles B HallDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
Andrew C ToddDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.
David G GoldfarbDepartment of Medicine, Montefiore Medical Center, New York, New York.
Maria J SchymuraBureau of Cancer Epidemiology, New York State Department of Health, Albany, New York.
Jiehui LiWorld Trade Center Health Registry, New York City Department of Health and Mental Hygiene, Long Island City, New York.
James E ConeWorld Trade Center Health Registry, New York City Department of Health and Mental Hygiene, Long Island City, New York.
Rachel Zeig-OwensDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
Albert Einstein College of Medicine · USNew York City Department of Health and Mental Hygiene · USIcahn School of Medicine at Mount Sinai · USNew York City Fire Department · USNew York State Department of Health · USStony Brook Medicine · US

Funding

Extension of the World Trade Center RegistryU50OH009739 · OH · NEW YORK CITY HEALTH/MENTAL HYGIENE · PI FARFEL, MARK R · 2009 to 2025
$120.0M
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
WORLD TRADE CENTER REGISTRYU50TS272750 · TS · NEW YORK CITY HEALTH/MENTAL HYGIENE · PI FARFEL, MARK R · 2005 to 2008
$12.3M
Mortality among WTC rescue and recovery workersU01OH011480 · OH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOFFETTA, PAOLO, HALL, CHARLES B · 2017 to 2020
$2.4M
Incidence, Latency, and Survival of Cancer Following World Trade Center ExposureU01OH011315 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BOFFETTA, PAOLO, HALL, CHARLES B · 2016 to 2018
$1.4M
Incidence, Latency, and Survival of Cancer Following World Trade Center ExposureU01OH011932 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HALL, CHARLES B · 2019 to 2019
$1.1M
Detection and Incidence of Thyroid Cancer among Three Cohorts of WTC-Exposed Rescue and Recovery WorkersU01OH011931 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ZEIG-OWENS, RACHEL · 2019 to 2019
$555k
Detection and Incidence of Thyroid Cancer among Three Cohorts of WTC-Exposed Rescue and Recovery WorkersU01OH011681 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ZEIG-OWENS, RACHEL · 2018 to 2018
$350k
ATSDR CDC HHS U50/ATU272750CDC HHS 6NU58DP006309NCI NIH HHS 75N91018D00005NCI NIH HHS P30 CA013330NIOSH CDC HHS 200-2017-93325NIOSH CDC HHS 200-2017-93326NIOSH CDC HHS HHSD200200200384CNIOSH CDC HHS HHSD200201139356CNIOSH CDC HHS HHSD200201139377CNIOSH CDC HHS HHSD200201793325CNIOSH CDC HHS U01 OH011315NIOSH CDC HHS U01OH011315NIOSH CDC HHS U01 OH011480NIOSH CDC HHS U01 OH011681NIOSH CDC HHS U01 OH011869NIOSH CDC HHS U01 OH011931NIOSH CDC HHS U01 OH011932NIOSH CDC HHS U50 OH009739NIOSH CDC HHS U50/OH009739
6 · The paper itself

Abstract

Twenty years after the September 11th, 2001 terrorist attacks, the association between exposures present at the World Trade Center (WTC) site and the risk of several specific types of cancer has been reported among rescue and recovery workers. The authors' objective was to conduct an updated review of these data. Most studies have found elevated rates of both prostate and thyroid cancers compared with rates in the general population, and some have reported statistically significant differences for the rates of all cancers as well. Studies including a larger combined cohort of WTC-exposed rescue and recovery workers from 3 main cohorts have since replicated findings for these cancers, with additional years of follow-up. Among this combined cohort, although a lower-than-expected standardized incidence ratio for all cancers was observed, WTC exposure was also related to an increased risk of cutaneous melanoma and tonsil cancer. Importantly, another study found that WTC-exposed rescue and recovery workers who are enrolled in the federally funded medical monitoring and treatment program experienced improved survival post-cancer diagnosis compared with New York state patients with cancer. On the basis of these combined cohort studies, the full effect of WTC exposure on cancer risk is becoming clearer. Consequently, the authors believe that surveillance of those with WTC exposure should be continued, and in-depth analysis of epidemiologic, molecular, and clinical aspects of specific cancers in these workers should be pursued.

Indexed as

MelanomaOccupational ExposureSeptember 11 Terrorist AttacksSkin NeoplasmsCohort StudiesHumansMaleRescue WorkdisastersepidemiologyneoplasmreviewSeptember 11 terrorist attacks

Identifiers

PMID35325473
PMCPMC12723702
OpenAlexW4221013282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.