Evidence map›Paper›PMID 35325363›Full record

ArticleJournal of biological physics2022

Investigation of extracellular medium osmolality depending on zinc application and incubation time on A549 cancer cells.

Duygu Tarhan, Nural Pastaci Özsobaci, Dilek Düzgün Ergün, Alev Meltem Ercan

Open access · greenAbstract read
In one paragraph

Article in Journal of biological physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Duygu TarhanCerrahpasa Faculty of Medicine, Department of Biophysics, Istanbul University-Cerrahpasa, Istanbul, Turkey. duygu.tarhan@iuc.edu.tr.ORCID 0000-0002-0878-5709
Nural Pastaci ÖzsobaciCerrahpasa Faculty of Medicine, Department of Biophysics, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID 0000-0002-9133-5695
Dilek Düzgün ErgünFaculty of Medicine, Department of Biophysics, Istanbul Aydin University, Istanbul, Turkey.ORCID 0000-0002-6245-6631
Alev Meltem ErcanCerrahpasa Faculty of Medicine, Department of Biophysics, Istanbul University-Cerrahpasa, Istanbul, Turkey.ORCID 0000-0002-4533-4907
Istanbul University-Cerrahpaşa · TRIstanbul Aydın University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in the osmolality of the extracellular medium (ECM) affect cell volume and cellular processes such as cell migration and proliferation. Not only may high concentrations of zinc (Zn) lead to cell death by apoptosis, but Zn is also a physiological suppressor of apoptosis. The aim of our study was to examine whether Zn and regulation of extracellular osmolality had an effect on the lung cancer cell line (A549) and how to be changed in ECM according to elements and osmolality depending on incubation time and Zn application. Our study consisted of four groups: cell-free medium, ECM of cancer cell after 24 h incubation (24hECM), ECM of cancer cell after 48 h incubation (48hECM), and ECM of cancer cell after 48 h incubation with ZnCl

Indexed as

NeoplasmsZincCulture MediaIronMagnesiumOsmolar ConcentrationCulture MediaIronMagnesiumZincA549Extracellular mediumIC50OsmolalityZinc

Identifiers

PMID35325363
PMCPMC9054989
OpenAlexW4220700891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.