Evidence map›Paper›PMID 35325357›Full record

ArticleStem cell reviews and reports2022

Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells.

Ana T Semeano, Fabiano A Tofoli, Juliana C Corrêa-Velloso, Ana P de Jesus Santos, Ágatha Oliveira-Giacomelli, Rafaela R Cardoso, Mateus A Pessoa, Edroaldo Lummertz da Rocha, Gustavo Ribeiro, Merari F R Ferrari and 4 more

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In one paragraph

Article in Stem cell reviews and reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ana T SemeanoDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes, 748. Sala 964 Bloco 9 Superior, Cidade Universitária, São Paulo, SP, 05508-000, Brazil.ORCID http://orcid.org/0000-0002-6995-2072
Fabiano A TofoliDepartment of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-3610-603X
Juliana C Corrêa-VellosoDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes, 748. Sala 964 Bloco 9 Superior, Cidade Universitária, São Paulo, SP, 05508-000, Brazil.ORCID http://orcid.org/0000-0002-1276-3844
Ana P de Jesus SantosDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes, 748. Sala 964 Bloco 9 Superior, Cidade Universitária, São Paulo, SP, 05508-000, Brazil.ORCID http://orcid.org/0000-0002-1137-5508
Ágatha Oliveira-GiacomelliDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes, 748. Sala 964 Bloco 9 Superior, Cidade Universitária, São Paulo, SP, 05508-000, Brazil.ORCID http://orcid.org/0000-0002-8666-9471
Rafaela R CardosoDepartment of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-1305-4916
Mateus A PessoaDepartment of Microbiology, Immunology and Parasitology at Federal University of Santa Catarina, Florianópolis, Brazil.ORCID http://orcid.org/0000-0001-9623-5960
Edroaldo Lummertz da RochaDepartment of Microbiology, Immunology and Parasitology at Federal University of Santa Catarina, Florianópolis, Brazil.ORCID http://orcid.org/0000-0003-0537-4223
Gustavo RibeiroDepartment of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-4667-9947
Merari F R FerrariDepartment of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-7396-2196
Lygia V PereiraDepartment of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-0002-725X
Yang D TengLaboratory of SCI, Stem Cell and Recovery Neurobiology Research, Department of Physical Medicine & Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital Network, and Mass General Brigham, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1257-4461
Denise F S PetriDepartment of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes, 748. Sala 307 Bloco 3 Inferior, Cidade Universitária, São Paulo, SP, 05508-000, Brazil. dfsp@iq.usp.br.ORCID http://orcid.org/0000-0003-4814-8357
Henning UlrichDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes, 748. Sala 964 Bloco 9 Superior, Cidade Universitária, São Paulo, SP, 05508-000, Brazil. henning@iq.usp.br.ORCID http://orcid.org/0000-0002-2114-3815
Universidade de São Paulo · BRUniversidade Federal de Santa Catarina · BRHarvard University · USNortheastern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodevelopmental processes of pluripotent cells, such as proliferation and differentiation, are influenced by external natural forces. Despite the presence of biogenic magnetite nanoparticles in the central nervous system and constant exposure to the Earth's magnetic fields and other sources, there is scant knowledge regarding the role of electromagnetic stimuli in neurogenesis. Moreover, emerging applications of electrical and magnetic stimulation to treat neurological disorders emphasize the relevance of understanding the impact and mechanisms behind these stimuli. Here, the effects of magnetic nanoparticles (MNPs) in polymeric coatings and the static external magnetic field (EMF) were investigated on neural induction of murine embryonic stem cells (mESCs) and human induced pluripotent stem cells (hiPSCs). The results show that the presence of 0.5% MNPs in collagen-based coatings facilitates the migration and neuronal maturation of mESCs and hiPSCs in vitro. Furthermore, the application of 0.4 Tesla EMF perpendicularly to the cell culture plane, discernibly stimulates proliferation and guide fate decisions of the pluripotent stem cells, depending on the origin of stem cells and their developmental stage. Mechanistic analysis reveals that modulation of ionic homeostasis and the expression of proteins involved in cytostructural, liposomal and cell cycle checkpoint functions provide a principal underpinning for the impact of electromagnetic stimuli on neural lineage specification and proliferation. These findings not only explore the potential of the magnetic stimuli as neural differentiation and function modulator but also highlight the risks that immoderate magnetic stimulation may affect more susceptible neurons, such as dopaminergic neurons.

Indexed as

Induced Pluripotent Stem CellsMagnetite NanoparticlesPluripotent Stem CellsAnimalsDopaminergic NeuronsHumansMagnetic FieldsMiceMagnetite NanoparticlesBiomagnetic effectsDopaminergic neuronsEmbryonic stem cellsiPSCsMagnetic fieldMagnetic nanoparticlesNeural differentiation

Identifiers

PMID35325357
OpenAlexW4221023952

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.