ArticlePlant physiology2022
MicroRNA858a, its encoded peptide, and phytosulfokine regulate Arabidopsis growth and development.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Characterization of phytosulfokine peptide family in cotton and its role in cold stress response.Functional & integrative genomics · 2026Article
- The microRNA-encoded peptide miPEP398b regulates heat tolerance in grapevine.Plant physiology · 2025Article
- A plant peptide with dual activity against multidrug-resistant bacterial and fungal pathogens.Science advances · 2025Article
- misORFPred: A Novel Method to Mine Translatable sORFs in Plant Pri-miRNAs Using Enhanced Scalable k-mer and Dynamic Ensemble Voting Strategy.Interdisciplinary sciences, computational life sciences · 2025Article
- Promising Biotechnological Applications of the Artificial Derivatives Designed and Constructed from Plant microRNA Genes.Plants (Basel, Switzerland) · 2025Review
- A micropeptide regulates seed desiccation.Frontiers in plant science · 2025Article
- Identification of multiple miRNA-encoded peptide reveals OsmiPEP162a putatively stabilizes OsMIR162 in rice.Plant cell reports · 2024Article
- EnhancingPlants (Basel, Switzerland) · 2024Article
- Sulfated peptides: key players in plant development, growth, and stress responses.Frontiers in plant science · 2024Review
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond.Journal of experimental botany · 2023Article
- microRNA408 and its encoded peptide regulate sulfur assimilation and arsenic stress response in Arabidopsis.Plant physiology · 2023Article
- Regulatory miPEP Open Reading Frames Contained in the Primary Transcripts of microRNAs.International journal of molecular sciences · 2023Review
- The Essentials on microRNA-Encoded Peptides from Plants to Animals.Biomolecules · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small molecules, such as peptides and miRNAs, are crucial regulators of plant growth. Here, we show the importance of cross-talk between miPEP858a (microRNA858a-encoded peptide)/miR858a and phytosulfokine (PSK4) in regulating plant growth and development in Arabidopsis (Arabidopsis thaliana). Genome-wide expression analysis suggested modulated expression of PSK4 in miR858a mutants and miR858a-overexpressing (miR858aOX) plants. The silencing of PSK4 in miR858aOX plants compromised growth, whereas overexpression of PSK4 in the miR858a mutant rescued the developmental defects. The exogenous application of synthetic PSK4 further complemented the plant development in mutant plants. Exogenous treatment of synthetic miPEP858a in the PSK4 mutant led to clathrin-mediated internalization of the peptide; however, it did not enhance growth as is the case in wild-type plants. We also demonstrated that MYB3 is an important molecular component participating in the miPEP858a/miR858a-PSK4 module. Finally, our work highlights the signaling between miR858a/miPEP858a-MYB3-PSK4 in modulating the expression of key elements involved in auxin responses, leading to the regulation of growth.
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