Evidence map›Paper›PMID 35325201›Full record

SynthesisPain medicine (Malden, Mass.)2022

Effectiveness of Pharmacological-Based Interventions, Including Education and Prescribing Strategies, to Reduce Subacute Pain After Total Hip or Knee Arthroplasty: A Systematic Review of Randomized Controlled Trials.

Shania Liu, Furkan Genel, Ian A Harris, Asad E Patanwala, Sam Adie, Jennifer Stevens, Geraldine Hassett, Kate Luckie, Jonathan Penm, Justine Naylor

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pain medicine (Malden, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Shania LiuFaculty of Medicine and Health, School of Pharmacy, The University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0001-7047-4621
Furkan GenelSt George and Sutherland Clinical School, University of New South Wales, Kogarah, NSW, Australia.
Ian A HarrisWhitlam Orthopaedic Research Centre, Ingham Institute, Liverpool, NSW, Australia.
Asad E PatanwalaFaculty of Medicine and Health, School of Pharmacy, The University of Sydney, Camperdown, NSW, Australia.
Sam AdieSt George and Sutherland Clinical School, University of New South Wales, Kogarah, NSW, Australia.
Jennifer StevensSchool of Clinical Medicine, University of New South Wales, Kensington, NSW, Australia.
Geraldine HassettSouth Western Sydney Clinical School, Faculty of Medicine, UNSW Sydney, Liverpool, NSW, Australia.
Kate LuckieMaridulu Budyari Gumal, Sydney Partnership of Health Education Research and Enterprise (SPHERE), Sydney, NSW, Australia.
Jonathan PenmFaculty of Medicine and Health, School of Pharmacy, The University of Sydney, Camperdown, NSW, Australia.
Justine NaylorWhitlam Orthopaedic Research Centre, Ingham Institute, Liverpool, NSW, Australia.
The University of Sydney · AUUNSW Sydney · AUSutherland Hospital · AULiverpool Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTotal knee arthroplasty (TKA) and total hip arthroplasty (THA) surgeries are among the most common elective procedures. Moderate to severe postoperative pain during the subacute period (defined here as the period from hospital discharge to 3 months postoperatively) is a predictor of persistent pain 12 months postoperatively. This review aimed to examine the available postdischarge pharmacological interventions, including educational and prescribing strategies, and their effect on reducing pain during the subacute period after TKA or THA.

methodsWe searched seven electronic databases from inception to April 22, 2021. Published randomized controlled trials of adults who underwent TKA or THA and received a pharmacological-based intervention commencing within 1 week after hospital discharge and conducted for up to 3 months postoperatively were compared with any treatment. Two reviewers independently extracted data on the primary outcome, pain intensity. This review was registered prospectively on PROSPERO (ID: CRD42021250384).

resultsFour trials involving 660 participants were included. Interventions included changing analgesic prescribing practices upon hospital discharge and education on analgesic use. Providing multimodal non-opioid analgesia in addition to reduced opioid quantity was associated with lower subacute pain (coefficient -0.81; 95% confidence interval -1.33 to -0.29; P = 0.003). Education on analgesic use during multidisciplinary home visits was effective for reducing pain intensity during the subacute period (6.25 ± 10.13 vs 35.67 ± 22.05; P < 0.001) compared with usual care.

conclusionsInterventions involving the provision of multimodal non-opioid analgesia and education on analgesic use show positive effects on reducing pain intensity during the subacute period after TKA and THA.

Indexed as

Arthroplasty, Replacement, HipArthroplasty, Replacement, KneeAdultAftercareAnalgesicsAnalgesics, OpioidHumansPatient DischargePostoperative PainRandomized Controlled Trials as TopicAnalgesicsAnalgesics, OpioidInterventionJoint ReplacementSubacute PainTotal Hip ArthroplastyTotal Knee Arthroplasty

Identifiers

PMID35325201
PMCPMC9434276
OpenAlexW4220725660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.