Evidence map›Paper›PMID 35325123›Full record

ArticleG3 (Bethesda, Md.)2022

Whole-genome sequence and methylome profiling of the almond [Prunus dulcis (Mill.) D.A. Webb] cultivar 'Nonpareil'.

Katherine M D'Amico-Willman, Wilberforce Z Ouma, Tea Meulia, Gina M Sideli, Thomas M Gradziel, Jonathan Fresnedo-Ramírez

Erratum issuedAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Genetic dissection of apricot fruit skin color (Molecular breeding : new strategies in plant improvement · 2026
    Article
  3. Article
  4. Mapping the genomic landscape ofHorticulture research · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
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  15. Article
  16. Spontaneous, Artificial, and Genome Editing-Mediated Mutations inInternational journal of molecular sciences · 2022
    Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Katherine M D'Amico-WillmanCenter for Applied Plant Sciences, The Ohio State University, Wooster, OH 44691, USA.
Wilberforce Z OumaOhio Supercomputer Center, Columbus, OH 43215, USA.
Tea MeuliaMolecular and Cellular Imaging Center, The Ohio State University, Wooster, OH 44691, USA.ORCID 0000-0001-7412-0433
Gina M SideliDepartment of Plant Sciences, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0003-1056-1496
Thomas M GradzielDepartment of Plant Sciences, University of California, Davis, Davis, CA 95616, USA.
Jonathan Fresnedo-RamírezDepartment of Horticulture and Crop Science, The Ohio State University, Wooster, OH 44691, USA.ORCID 0000-0003-1985-2513

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

Almond [Prunus dulcis (Mill.) D.A. Webb] is an economically important, specialty nut crop grown almost exclusively in the United States. Breeding and improvement efforts worldwide have led to the development of key, productive cultivars, including 'Nonpareil,' which is the most widely grown almond cultivar. Thus far, genomic resources for this species have been limited, and a whole-genome assembly for 'Nonpareil' is not currently available despite its economic importance and use in almond breeding worldwide. We generated a 571X coverage genome sequence using Illumina, PacBio, and optical mapping technologies. Gene prediction revealed 49,321 putative genes using MinION Oxford nanopore and Illumina RNA sequencing, and genome annotation found that 68% of predicted models are associated with at least one biological function. Furthermore, epigenetic signatures of almond, namely DNA cytosine methylation, have been implicated in a variety of phenotypes including self-compatibility, bud dormancy, and development of noninfectious bud failure. In addition to the genome sequence and annotation, this report also provides the complete methylome of several almond tissues, including leaf, flower, endocarp, mesocarp, exocarp, and seed coat. Comparisons between methylation profiles in these tissues revealed differences in genome-wide weighted % methylation and chromosome-level methylation enrichment.

Indexed as

Prunus dulcisEpigenomeFlowersGenome, PlantPlant Breedingalmondcytosine methylationenzymatic methylation sequencingmultiplatform genome assemblyNonpareil

Identifiers

PMID35325123
PMCPMC9073694

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.