Evidence map›Paper›PMID 35325119›Full record

ArticleGenome biology and evolution2022

High-Resolution Estimates of Crossover and Noncrossover Recombination from a Captive Baboon Colony.

Jeffrey D Wall, Jacqueline A Robinson, Laura A Cox

Open access · goldAbstract read
In one paragraph

Article in Genome biology and evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  5. Census and genetic analysis of the United States marmoset population.bioRxiv : the preprint server for biology · 2026
    Article
  6. Fine-scale recombination rates inferred using the canFam4 assembly are strongly correlated with previous maps of dog recombination.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  7. Review
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  20. Estimating realized relatedness in free-ranging macaques by inferring identity-by-descent segments.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jeffrey D WallInstitute for Human Genetics, University of California San Francisco, USA.
Jacqueline A RobinsonInstitute for Human Genetics, University of California San Francisco, USA.
Laura A CoxCenter for Precision Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, USA.
University of California, San Francisco · USWake Forest University · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Development of a pedigreed baboon genome resource for biomedical researchR24OD017859 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COX, LAURA A, WALL, JEFFREY D · 2014 to 2017
$3.2M
Estimating fine scale changes in recombination rates across speciesR01GM115433 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WALL, JEFFREY D · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM115433NIH HHS P51 OD011133NIH HHS R24 OD017859
6 · The paper itself

Abstract

Homologous recombination has been extensively studied in humans and a handful of model organisms. Much less is known about recombination in other species, including nonhuman primates. Here, we present a study of crossovers (COs) and noncrossover (NCO) recombination in olive baboons (Papio anubis) from two pedigrees containing a total of 20 paternal and 17 maternal meioses, and compare these results to linkage disequilibrium (LD) based recombination estimates from 36 unrelated olive baboons. We demonstrate how COs, combined with LD-based recombination estimates, can be used to identify genome assembly errors. We also quantify sex-specific differences in recombination rates, including elevated male CO and reduced female CO rates near telomeres. Finally, we add to the increasing body of evidence suggesting that while most NCO recombination tracts in mammals are short (e.g., <500 bp), there is a non-negligible fraction of longer (e.g., >1 kb) NCO tracts. For NCO tracts shorter than 10 kb, we fit a mixture of two (truncated) geometric distributions model to the NCO tract length distribution and estimate that >99% of all NCO tracts are very short (mean 24 bp), but the remaining tracts can be quite long (mean 4.3 kb). A single geometric distribution model for NCO tract lengths is incompatible with the data, suggesting that LD-based methods for estimating NCO recombination rates that make this assumption may need to be modified.

Indexed as

Crossing Over, GeneticMeiosisAnimalsFemaleMaleMammalsPapioPedigreelinkage disequilibriumnoncrossoversnonhuman primatesrecombination

Identifiers

PMID35325119
PMCPMC9048888
OpenAlexW4220953948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.