ArticleCerebral cortex (New York, N.Y. : 1991)2023
Adaptive and pathological connectivity responses in Parkinson's disease brain networks.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Parkinson's disease: Individual placebo responses are predicted by baseline expression of a striato-limbic network.Research square · 2026Article
- Non-invasive identification of brain signatures of acute liver injury.Theranostics · 2026Article
- Multimodal metabolic and functional network signatures for diagnosis of parkinson's disease: a PET/MR study.Scientific reports · 2025Article
- An artificial intelligence-derived metabolic network predicts psychosis in Alzheimer's disease.Brain communications · 2025Article
- Article
- Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder.Nature communications · 2024Article
- Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats.International journal of molecular sciences · 2024Article
- Longitudinal Network Changes and Phenoconversion Risk in Isolated REM Sleep Behavior Disorder.Research square · 2024Article
- The Role of a Dopamine-Dependent Limbic-Motor Network in Sensory Motor Processing in Parkinson Disease.Journal of cognitive neuroscience · 2023Article
- Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Disordered network structure and function in dystonia: pathological connectivity vs. adaptive responses.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Disease specific and nonspecific metabolic brain networks in behavioral variant of frontotemporal dementia.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Functional imaging has been used extensively to identify and validate disease-specific networks as biomarkers in neurodegenerative disorders. It is not known, however, whether the connectivity patterns in these networks differ with disease progression compared to the beneficial adaptations that may also occur over time. To distinguish the 2 responses, we focused on assortativity, the tendency for network connections to link nodes with similar properties. High assortativity is associated with unstable, inefficient flow through the network. Low assortativity, by contrast, involves more diverse connections that are also more robust and efficient. We found that in Parkinson's disease (PD), network assortativity increased over time. Assoratitivty was high in clinically aggressive genetic variants but was low for genes associated with slow progression. Dopaminergic treatment increased assortativity despite improving motor symptoms, but subthalamic gene therapy, which remodels PD networks, reduced this measure compared to sham surgery. Stereotyped changes in connectivity patterns underlie disease progression and treatment responses in PD networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.