Evidence map›Paper›PMID 35324987›Full record

ArticlePloS one2022

Mapping local hot spots with routine tuberculosis data: A pragmatic approach to identify spatial variability.

Meredith B Brooks, Ana Karina Millones, Daniela Puma, Carmen Contreras, Judith Jimenez, Christine Tzelios, Helen E Jenkins, Courtney M Yuen, Salmaan Keshavjee, Leonid Lecca and 1 more

Abstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Spatial Distribution of Drug-ResistantPathogens (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meredith B BrooksDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.ORCID 0000-0003-1022-2515
Ana Karina MillonesSocios En Salud Sucursal Perú, Lima, Peru.
Daniela PumaSocios En Salud Sucursal Perú, Lima, Peru.
Carmen ContrerasSocios En Salud Sucursal Perú, Lima, Peru.
Judith JimenezSocios En Salud Sucursal Perú, Lima, Peru.
Christine TzeliosDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Helen E JenkinsBoston University School of Public Health, Department of Biostatistics, Boston, Massachusetts, United States of America.
Courtney M YuenDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Salmaan KeshavjeeDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Leonid LeccaDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Mercedes C BecerraDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.

Funding

New approaches to optimizing the application and measuring the impact of community-based tuberculosis interventionsDP2MD015102 · NIMHD · BRIGHAM AND WOMEN'S HOSPITAL · PI YUEN, COURTNEY M. · 2019 to 2019
$2.4M
Tuberculosis in teens: a geospatial approach to predict community transmissionK01AI151083 · NIAID · HARVARD MEDICAL SCHOOL · PI Meredith Blair Brooks · 2021 to 2026
$698k
NIAID NIH HHS K01 AI151083NIMHD NIH HHS DP2 MD015102
6 · The paper itself

Abstract

objectiveTo use routinely collected data, with the addition of geographic information and census data, to identify local hot spots of rates of reported tuberculosis cases.

designResidential locations of tuberculosis cases identified from eight public health facilities in Lima, Peru (2013-2018) were linked to census data to calculate neighborhood-level annual case rates. Heat maps of tuberculosis case rates by neighborhood were created. Local indicators of spatial autocorrelation, Moran's I, were used to identify where in the study area spatial clusters and outliers of tuberculosis case rates were occurring. Age- and sex-stratified case rates were also assessed.

resultsWe identified reports of 1,295 TB cases across 74 neighborhoods during the five-year study period, for an average annual rate of 124.2 reported TB cases per 100,000 population. In evaluating case rates by individual neighborhood, we identified a median rate of reported cases of 123.6 and a range from 0 to 800 cases per 100,000 population. Individuals aged 15-44 years old and men had higher case rates than other age groups and women. Locations of both hot and cold spots overlapped across age- and gender-specific maps.

conclusionsThere is significant geographic heterogeneity in rates of reported TB cases and evident hot and cold spots within the study area. Characterization of the spatial distribution of these rates and local hot spots may be one practical tool to inform the work of local coalitions to target TB interventions in their zones.

Indexed as

TuberculosisAdolescentAdultFemaleHumansMalePeruSpatial AnalysisYoung Adult

Identifiers

PMID35324987
PMCPMC8947086

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.