Evidence map›Paper›PMID 35324733›Full record

ArticleToxics2022

Effect of Cosmetics Use on the In Vitro Skin Absorption of a Biocide, 1,2-Benzisothiazolin-3-one.

Yoonjung Huh, Do-Hyeon Lee, Dalwoong Choi, Kyung-Min Lim

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06434519 (Evaluation of the Effect of Moisturizers on the Absorption of Metronidazole Into the Stratum Corneum of Rosacea Patients With Tape Stripping and Liquid Chromatography-mass Spectrometry), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06434519 nacompletednot on this mapstarted 2024, after this paper: background citation

Evaluation of the Effect of Moisturizers on the Absorption of Metronidazole Into the Stratum Corneum of Rosacea Patients With Tape Stripping and Liquid Chromatography-mass Spectrometry

TypeinterventionalSponsorDuke UniversityRan2024 to 2025Enrolled21ConditionsRosacea, ErythematotelangiectaticArmsMetronidazole cream, Cetaphil moisturizer, CeraVe moisturizer, Eucerin Healing Lotion moisturizer, Aveeno Calm and Restore Oat Gel moisturizer
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoonjung HuhCollege of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Do-Hyeon LeeTransdisciplinary Major in Learning Health Systems, Department of Health and Safety Convergence Science, Korea University, Seoul 02481, Korea.
Dalwoong ChoiTransdisciplinary Major in Learning Health Systems, Department of Health and Safety Convergence Science, Korea University, Seoul 02481, Korea.
Kyung-Min LimCollege of Pharmacy, Ewha Womans University, Seoul 03760, Korea.ORCID 0000-0002-1517-7680

Funding

Korea Environment Industry & Technology Institute 2020002970001the National Research Foundation of Korea 2021R1A2C2013347
6 · The paper itself

Abstract

1,2-Benzisothiazolin-3-one (BIT) is a commonly used organic biocide containing an isothiazolone ring. However, it may have adverse effects on human health and its risk needs to be properly evaluated. Dermal exposure is the main route of BIT exposure, and co-exposed substances may affect its absorption. The dermal permeation profile of BIT has not been well-studied. This study aimed to investigate the dermal permeation profiles of BIT with or without cosmetic use. Dermal permeation profiles of BIT were investigated after infinite- (100 μg/cm

Indexed as

1,2-Benzisothiazolin-3-onecosmeticsisothiazolinonesrisk assessmentskin absorption

Identifiers

PMID35324733
PMCPMC8948713

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.