Evidence map›Paper›PMID 35324722›Full record

ArticleToxins2022

A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic

Fabian Rivera-Chávez, Bradley T Meader, Sinan Akosman, Vuk Koprivica, John J Mekalanos

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Cholera toxin as a model ABArchives of toxicology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Structural basis for CFTR inhibition by CFTRProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas.Translational research : the journal of laboratory and clinical medicine · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Fabian Rivera-ChávezDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, CA 92093, USA.
Bradley T MeaderDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Sinan AkosmanVanda Pharmaceuticals, Inc., Washington, DC 20037, USA.
Vuk KoprivicaVanda Pharmaceuticals, Inc., Washington, DC 20037, USA.
John J MekalanosDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Harvard University · USVanda Pharmaceuticals (United States) · USUniversity of California, San Diego · US

Funding

INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CholeraVibrio choleraeAnimalsCholera ToxinCystic Fibrosis Transmembrane Conductance RegulatorDiarrheaMiceMorbidityCholera ToxinCystic Fibrosis Transmembrane Conductance Regulatoranti-infective drug therapycholera toxindiarrheal syndromesVibrio cholerae

Identifiers

PMID35324722
PMCPMC8948642
OpenAlexW4220767647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.