ArticleProceedings of the National Academy of Sciences of the United States of America2022
Engineered CaM2 modulates nuclear calcium oscillation and enhances legume root nodule symbiosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- CNGCs in Marchantia paleacea uncouple arbuscular mycorrhizal symbiosis and rhizoid development.The New phytologist · 2026Article
- Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026Review
- Review
- Transcriptomic Comparison of Soybean Roots Inoculated with Different Rhizobium Strains During Early Symbiosis.Plants (Basel, Switzerland) · 2026Article
- Cyclic nucleotide-gated channels serve as core components for CaJournal of plant research · 2026Article
- Zea Maize Calmodulin (Plants (Basel, Switzerland) · 2025Article
- Structural basis for the activity regulation of Medicago calcium channel CNGC15.Cell discovery · 2025Article
- Unravelling the Molecular Dialogue of Beneficial Microbe-Plant Interactions.Plant, cell & environment · 2025Review
- Article
- Article
- A new type III effector from Bradyrhizobium sp. DOA9 encoding a putative SUMO-protease blocks nodulation in Arachis hypogaea L.Scientific reports · 2024Article
- Annexin- and calcium-regulated priming of legume root cells for endosymbiotic infection.Nature communications · 2024Article
- Metal nutrition and transport in the process of symbiotic nitrogen fixation.Plant communications · 2024Review
- A novel mutant allele of AtCNGC15 reveals a dual function of nuclear calcium release in the root meristem.Journal of experimental botany · 2023Article
- Calcium/calmodulin-mediated microbial symbiotic interactions in plants.Frontiers in plant science · 2022Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SignificanceOscillations in intracellular calcium concentration play an essential role in the regulation of multiple cellular processes. In plants capable of root endosymbiosis with nitrogen-fixing bacteria and/or arbuscular mycorrhizal fungi, nuclear localized calcium oscillations are essential to transduce the microbial signal. Although the ion channels required to generate the nuclear localized calcium oscillations have been identified, their mechanisms of regulation are unknown. Here, we combined proteomics and engineering approaches to demonstrate that the calcium-bound form of the calmodulin 2 (CaM2) associates with CYCLIC NUCLEOTIDE GATED CHANNEL 15 (CNGC15s), closing the channels and providing the negative feedback to sustain the oscillatory mechanism. We further unraveled that the engineered CaM2 accelerates early endosymbioses and enhanced root nodule symbiosis but not arbuscular mycorrhization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.