Evidence map›Paper›PMID 35324316›Full record

ArticleMolecular biology of the cell2022

TAK1 is essential for endothelial barrier maintenance and repair after lung vascular injury.

Dong-Mei Wang, Dheeraj Soni, Sushil C Regmi, Stephen M Vogel, Chinnaswamy Tiruppathi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. TAK1 in Vascular Signaling: "Friend or Foe"?Journal of inflammation research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dong-Mei WangDepartment of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois, Chicago, IL 60612.
Dheeraj SoniDepartment of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois, Chicago, IL 60612.
Sushil C RegmiDepartment of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois, Chicago, IL 60612.
Stephen M VogelDepartment of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois, Chicago, IL 60612.
Chinnaswamy TiruppathiDepartment of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois, Chicago, IL 60612.
University of Illinois Urbana-Champaign · US

Funding

Transcription Factor Elf2 Signals Resolution of Lung InjuryR01HL156965 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2021 to 2024
$2.1M
Endothelial TAK1 Signaling and Resolution of Pulmonary Edema in SepsisR01GM117028 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2016 to 2019
$1.3M
Novel E3 Ubiquitin Ligase CHFR Regulates Endothelial Barrier Integrity and Innate Immune FunctionR01GM138499 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2021 to 2022
$416k
NHLBI NIH HHS R01 HL156965NIGMS NIH HHS R01 GM117028NIGMS NIH HHS R01 GM138499
6 · The paper itself

Abstract

TGF-β-activated kinase 1 (TAK1) plays crucial roles in innate and adaptive immune responses and is required for embryonic vascular development. However, TAK1's role in regulating vascular barrier integrity is not well defined. Here we show that endothelial TAK1 kinase function is required to maintain and repair the injured lung endothelial barrier. We observed that inhibition of TAK1 with 5Z-7-oxozeaenol markedly reduced expression of β-catenin (β-cat) and VE-cadherin at endothelial adherens junctions and augmented protease-activated receptor-1 (PAR-1)- or toll-like receptor-4 (TLR-4)-induced increases in lung vascular permeability. In inducible endothelial cell (EC)-restricted TAK1 knockout (

Indexed as

Toll-Like Receptor 4Vascular System InjuriesAnimalsGlycogen Synthase Kinase 3 betaLungMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMiceProto-Oncogene Proteins c-aktGlycogen Synthase Kinase 3 betaMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesProto-Oncogene Proteins c-aktToll-Like Receptor 4

Identifiers

PMID35324316
PMCPMC9561857
OpenAlexW4220894279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.