Evidence map›Paper›PMID 35324203›Full record

ArticleOrganic letters2022

4-Aminobenzotriazole (ABTA) as a Removable Directing Group for Palladium-Catalyzed Aerobic Oxidative C-H Olefination.

Zhuo Wang, Xiaohan Ye, Meina Jin, Qi Tang, Shengyu Fan, Zhiguang Song, Xiaodong Shi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Zhuo WangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Jilin, Changchun 130012, P. R. hina.
Xiaohan YeDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Meina JinState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Jilin, Changchun 130012, P. R. hina.
Qi TangDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Shengyu FanState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Jilin, Changchun 130012, P. R. hina.
Zhiguang SongState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Jilin, Changchun 130012, P. R. hina.
Xiaodong ShiDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.ORCID 0000-0002-3189-1315
Jilin University · CNUniversity of South Florida · US

Funding

Achieving challenging coupling with gold redox catalysisR01GM120240 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI SHI, XIAODONG · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM120240
6 · The paper itself

Abstract

4-Aminobenzotriazole (ABTA) was applied as an effective removable directing group (DG) in Pd-catalyzed C-H activation for the first time. Compared with the widely applied pyridine and quinoline analogs, ABTA showed significantly improved reactivity, achieving aerobic oxidative C-H olefination in excellent yields (up to 95% vs <50% with other reported DGs under identical conditions). Using this new strategy, macrocyclization was achieved to give cyclic peptides in good yields with easy ABTA removal under mild conditions, highlighting the promising potential of this new DG.

Indexed as

AlkenesPalladiumCatalysisOxidation-ReductionOxidative StressAlkenesPalladium

Identifiers

PMID35324203
PMCPMC10264207
OpenAlexW4220747370

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.