Evidence map›Paper›PMID 35324198›Full record

ArticleJournal of the American Chemical Society2022

Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex.

Kane T McQuaid, Shuntaro Takahashi, Lena Baumgaertner, David J Cardin, Neil G Paterson, James P Hall, Naoki Sugimoto, Christine J Cardin

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 43 citations in OpenAlex.

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  12. Phen-DCAngewandte Chemie (International ed. in English) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kane T McQuaidDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.ORCID 0000-0002-3222-5584
Shuntaro TakahashiFIBER (Frontier Institute for Biomolecular Engineering Research), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.ORCID 0000-0002-7569-1761
Lena BaumgaertnerDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.
David J CardinDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.
Neil G PatersonDiamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, U.K.
James P HallSchool of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, U.K.ORCID 0000-0003-3716-4378
Naoki SugimotoFIBER (Frontier Institute for Biomolecular Engineering Research), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.ORCID 0000-0001-6161-9817
Christine J CardinDepartment of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, U.K.ORCID 0000-0002-2556-9995
University of Reading · GBKonan University · JPDiamond Light Source · GB

Funding

Biotechnology and Biological Sciences Research Council BB/T008342/1
6 · The paper itself

Abstract

The DNA G-quadruplex is known for forming a range of topologies and for the observed lability of the assembly, consistent with its transient formation in live cells. The stabilization of a particular topology by a small molecule is of great importance for therapeutic applications. Here, we show that the ruthenium complex Λ-[Ru(phen)

Indexed as

G-QuadruplexesRutheniumCircular DichroismDNAHumansTelomereDNARuthenium

Identifiers

PMID35324198
PMCPMC8991003
OpenAlexW4221002460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.