Evidence map›Paper›PMID 35324171›Full record

ArticleEnvironmental science & technology2022

Widening the Lens on PFASs: Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs).

Carrie A McDonough, Wenting Li, Heather N Bischel, Amila O De Silva, Jamie C DeWitt

Open access · greenAbstract read
In one paragraph

Article in Environmental science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Carrie A McDonoughDepartment of Civil Engineering, Stony Brook University, Stony Brook, New York 11794, United States.ORCID 0000-0001-5152-8495
Wenting LiDepartment of Civil & Environmental Engineering, University of California Davis, Davis, California 95616 United States.ORCID 0000-0002-6387-849X
Heather N BischelDepartment of Civil & Environmental Engineering, University of California Davis, Davis, California 95616 United States.
Amila O De SilvaAquatic Contaminants Research Division, Water Science Technology Directorate, Environment and Climate Change Canada, Burlington, Ontario L7S 1A1, Canada.ORCID 0000-0002-5126-8854
Jamie C DeWittDepartment of Pharmacology & Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, United States.
University of California, Davis · USEast Carolina University · USEnvironment and Climate Change Canada · CAStony Brook University · US

Funding

Uncovering the Mechanisms of PFAS-induced ImmunotoxicityP42ES031009 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOPPIN, JANE · 2020 to 2024
$9.3M
NIEHS NIH HHS P42 ES031009
6 · The paper itself

Abstract

Determining health risks associated with per-/polyfluoroalkyl substances (PFASs) is a highly complex problem requiring massive efforts for scientists, risk assessors, and regulators. Among the most poorly understood pressing questions is the relative importance of pre-PFAAs, which are PFASs that degrade to highly persistent perfluoroalkyl acids. How many of the vast number of existing pre-PFAAs are relevant for direct human exposure, and what are the predominant exposure pathways? What evidence of direct exposure to pre-PFAAs is provided by human biomonitoring studies? How important are pre-PFAAs and their biotransformation products for human health risk assessment? This article outlines recent progress and recommendations toward widening the lens on human PFAS exposure to include the pre-PFAA subclass.

Indexed as

FluorocarbonsWater Pollutants, ChemicalAnimalsBiotransformationFishesHumansFluorocarbonsWater Pollutants, Chemicalbioaccumulationbiotransformationhuman exposurenontarget analysisper- and polyfluoroalkyl substancesPFASsprecursorrisk assessment

Identifiers

PMID35324171
PMCPMC10782884
OpenAlexW4220999079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.