ArticleJournal of biomedical optics2022
Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: a comparison of colorimetry with spatial frequency domain imaging.
Article in Journal of biomedical optics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Unifying the spectrum: a framework for the meta-analysis of human skin tone scales.Journal of biomedical optics · 2026Pooled it
- Rapid noncontact laser speckle imaging for perfusion-based differentiation of wound necrosis.iScience · 2026Article
- Decoding melanin dynamics: Photoacoustic microscopy reveals differential aging of metabolic and keratinized skin zones.Photoacoustics · 2026Article
- Accuracy and Bias of Pulse Oximetry in the Intensive Care Unit: A Prospective Observational Study.Nursing in critical care · 2026Observational
- Optical phantoms for the characterization and validation of imaging and spectroscopy: a review.Biophotonics discovery · 2026Review
- Digital instrument simulator platform to support the development of noninvasive optical NIR device for placenta monitoring.Journal of biomedical optics · 2026Article
- Two-step regression analysis approach to assess burn wound severity using spatial frequency domain imaging.Journal of biomedical optics · 2026Article
- Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging.Photoacoustics · 2025Article
- Structured light imaging mesoscopy: application to skin changes in scleroderma.Biophotonics discovery · 2025Article
- Melanometry for objective evaluation of skin pigmentation in pulse oximetry studies.Communications medicine · 2024Review
- Mapping cutaneous field carcinogenesis of nonmelanoma skin cancer using mesoscopic imaging of pro-inflammation cues.Experimental dermatology · 2024Review
- Effect of skin color on optical properties and the implications for medical optical technologies: a review.Journal of biomedical optics · 2024Review
- Effects of skin tone on photoacoustic imaging and oximetry.Journal of biomedical optics · 2024Article
- Absorption and reduced scattering coefficients in epidermis and dermis from a Swedish cohort study.Journal of biomedical optics · 2023Article
- Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content.Journal of biomedical optics · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
significanceSpatial frequency domain imaging (SFDI) is a wide-field diffuse optical imaging technique for separately quantifying tissue reduced scattering (μs ' ) and absorption (μa) coefficients at multiple wavelengths, providing wide potential utility for clinical applications such as burn wound characterization and cancer detection. However, measured μs ' and μa can be confounded by absorption from melanin in patients with highly pigmented skin. This issue arises because epidermal melanin is highly absorbing for visible wavelengths and standard homogeneous light-tissue interaction models do not properly account for this complexity. Tristimulus colorimetry (which quantifies pigmentation using the L * "lightness" parameter) can provide a point of comparison between μa, μs ' , and skin pigmentation.
aimWe systematically compare SFDI and colorimetry parameters to quantify confounding effects of pigmentation on measured skin μs ' and μa. We assess the correlation between SFDI and colorimetry parameters as a function of wavelength. APPROACH: μs ' and μa from the palm and ventral forearm were measured for 15 healthy subjects with a wide range of skin pigmentation levels (Fitzpatrick types I to VI) using a Reflect RS® (Modulim, Inc., Irvine, California) SFDI instrument (eight wavelengths, 471 to 851 nm). L * was measured using a Chroma Meter CR-400 (Konica Minolta Sensing, Inc., Tokyo). Linear correlation coefficients were calculated between L * and μs ' and between L * and μa at all wavelengths.
resultsFor the ventral forearm, strong linear correlations between measured L * and μs ' values were observed at shorter wavelengths (R > 0.92 at ≤659 nm), where absorption from melanin confounded the measured μs ' . These correlations were weaker for the palm (R < 0.59 at ≤659 nm), which has less melanin than the forearm. Similar relationships were observed between L * and μa.
conclusionsWe quantified the effects of epidermal melanin on skin μs ' and μa measured with SFDI. This information may help characterize and correct pigmentation-related inaccuracies in SFDI skin measurements.
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