ArticleCerebral cortex (New York, N.Y. : 1991)2023
Rapid processing of threatening faces in the amygdala of nonhuman primates: subcortical inputs and dual roles.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Comparative neuroanatomy of emotion expression: from flies to humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Neuronal processing of facial expressions in the primate superior colliculus.bioRxiv : the preprint server for biology · 2026Article
- Weakening of Subcortical and Strengthening of Cortical Visual Pathways Across Early Adolescence.Human brain mapping · 2026Article
- A conserved pulvinar projection to the amygdala revealed in macaque monkeys (Macaca mulatta).Brain structure & function · 2026Article
- Visual activity in primate superior colliculus requires geniculostriate input.bioRxiv : the preprint server for biology · 2026Article
- Utilizing the Walla Emotion Model to Standardize Terminological Clarity for AI-Driven "Emotion" Recognition.Brain sciences · 2026Article
- Early face deprivation leads to long-lasting deficits in cortical face processing.bioRxiv : the preprint server for biology · 2026Article
- Editorial: Processing of face and other animacy cues in the brain.Frontiers in psychology · 2026Article
- Differential and Temporally Dynamic Involvement of Primate Amygdala Nuclei in Face Reality and Reward Information Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Face pareidolia minimally engages macaque face selective neurons.Progress in neurobiology · 2025Article
- Temporal Lobectomy Evidence for the Role of the Amygdala in Early Emotional Face and Body Processing.eNeuro · 2025Article
- Neuronal Mechanisms Underlying Face Recognition in Non-human Primates.The Japanese psychological research · 2024Article
- Short-latency preference for faces in primate superior colliculus depends on visual cortex.Neuron · 2024Article
- Article
- Beyond faces: the contribution of the amygdala to visual processing in the macaque brain.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions.Frontiers in neuroscience · 2024Review
- Face detection mechanisms: NatureFrontiers in neuroscience · 2024Review
- Analysis of convolutional neural networks reveals the computational properties essential for subcortical processing of facial expression.Scientific reports · 2023Article
- Convolutional neural networks reveal differences in action units of facial expressions between face image databases developed in different countries.Frontiers in psychology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A subcortical pathway through the superior colliculus and pulvinar has been proposed to provide the amygdala with rapid but coarse visual information about emotional faces. However, evidence for short-latency, facial expression-discriminating responses from individual amygdala neurons is lacking; even if such a response exists, how it might contribute to stimulus detection is unclear. Also, no definitive anatomical evidence is available for the assumed pathway. Here we showed that ensemble responses of amygdala neurons in monkeys carried robust information about open-mouthed, presumably threatening, faces within 50 ms after stimulus onset. This short-latency signal was not found in the visual cortex, suggesting a subcortical origin. Temporal analysis revealed that the early response contained excitatory and suppressive components. The excitatory component may be useful for sending rapid signals downstream, while the sharpening of the rising phase of later-arriving inputs (presumably from the cortex) by the suppressive component might improve the processing of facial expressions over time. Injection of a retrograde trans-synaptic tracer into the amygdala revealed presumed monosynaptic labeling in the pulvinar and disynaptic labeling in the superior colliculus, including the retinorecipient layers. We suggest that the early amygdala responses originating from the colliculo-pulvino-amygdalar pathway play dual roles in threat detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.