Evidence map›Paper›PMID 35323874›Full record

ReviewGenetics2022

Nematode chromosomes.

Peter M Carlton, Richard E Davis, Shawn Ahmed

Open access · hybridAbstract readReview
In one paragraph

Review in Genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 50 citations in OpenAlex.

  1. T2T genomes ofGenome research · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. CGC1, a new reference genome forGenome research · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. First comparative proteomic andFrontiers in veterinary science · 2025
    Article
  18. Inference of essential genes inComputational and structural biotechnology journal · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Peter M CarltonGraduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0002-5320-6024
Richard E DavisDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Denver, CO 80045, USA.ORCID 0000-0003-2242-3234
Shawn AhmedDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6365-2194
Kyoto University · JPUniversity of Colorado Denver · USUniversity of North Carolina at Chapel Hill · US

Funding

Chromatin diminution in nematodesR01AI114054 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DAVIS, RICHARD E. · 2015 to 2019
$2.5M
Small RNAs and telomere biologyR01GM135470 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AHMED, SHAWN CAMERON · 2020 to 2023
$1.4M
NIAID NIH HHS R01 AI114054NIGMS NIH HHS R01 GM135470
6 · The paper itself

Abstract

The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic biology, including genetics, development, cell biology, and genomics. A major factor in the success of C. elegans as a model organism has been the availability, since the late 1990s, of an essentially gap-free and well-annotated nuclear genome sequence, divided among 6 chromosomes. In this review, we discuss the structure, function, and biology of C. elegans chromosomes and then provide a general perspective on chromosome biology in other diverse nematode species. We highlight malleable chromosome features including centromeres, telomeres, and repetitive elements, as well as the remarkable process of programmed DNA elimination (historically described as chromatin diminution) that induces loss of portions of the genome in somatic cells of a handful of nematode species. An exciting future prospect is that nematode species may enable experimental approaches to study chromosome features and to test models of chromosome evolution. In the long term, fundamental insights regarding how speciation is integrated with chromosome biology may be revealed.

Indexed as

Caenorhabditis elegansNematodaAnimalsCentromereChromatinChromosomesTelomereChromatincentromereholocentricmeiosisprogrammed DNA eliminationrepetitive DNAsyntenytelomereWormBook

Identifiers

PMID35323874
PMCPMC9071541
OpenAlexW4220654443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.