Evidence map›Paper›PMID 35323659›Full record

ArticleMetabolites2022

Whole Blood Metabolite Profiles Reflect Changes in Energy Metabolism in Heart Failure.

Carl Beuchel, Julia Dittrich, Janne Pott, Sylvia Henger, Frank Beutner, Berend Isermann, Markus Loeffler, Joachim Thiery, Uta Ceglarek, Markus Scholz

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Carl BeuchelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany.ORCID 0000-0003-3224-3894
Julia DittrichInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany.
Janne PottInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany.ORCID 0000-0002-5983-5331
Sylvia HengerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany.
Frank BeutnerHeart Center Leipzig, 04289 Leipzig, Germany.
Berend IsermannInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-0714-6160
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany.
Joachim ThieryInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0001-7606-1852
Uta CeglarekInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany.ORCID 0000-0002-4059-1779
Leipzig University · DEUniversity Hospital Leipzig · DEChristian-Albrechts-Universität zu Kiel · DELeipzig Heart Institute · DE

Funding

European Union 713-24120Federal Ministry of Education and Research 01ZX1906BFree State of Saxony within the framework of the excellence initiative 14505/2470HELIOS, University of Leipzig and the Roland Ernst FoundationLeipzig Research Center for Civilization Diseases
6 · The paper itself

Abstract

A variety of atherosclerosis and cardiovascular disease (ASCVD) phenotypes are tightly linked to changes in the cardiac energy metabolism that can lead to a loss of metabolic flexibility and to unfavorable clinical outcomes. We conducted an association analysis of 31 ASCVD phenotypes and 97 whole blood amino acids, acylcarnitines and derived ratios in the LIFE-Adult (

Indexed as

acylcarnitinesamino acidsassociation studycardiovascular diseasecoronary artery diseasefatty acid oxidationgene expressionobservational studies

Identifiers

PMID35323659
PMCPMC8949022
OpenAlexW4214680007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.