ReviewMetabolites2022
Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance.
Review in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Eight weeks of aerobic exercise, but not four, improves insulin sensitivity and cardiovascular performance in young women.Scientific reports · 2025Trial
- Reversal of proteomic aging with exercise-results from the UK biobank and a 12-week intervention study.npj aging · 2025Article
- Diabetologists' Knowledge and Prescription of Physical Activity in Southeast Europe.Medicina (Kaunas, Lithuania) · 2025Article
- The associations of physical activity patterns and the triglyceride-glucose index in US adults: a secondary data analysis of NHANES (2007-2018).Scientific reports · 2025Article
- The Power of Movement: Linking Physical Activity with Nutritional Health and Blood Sugar Balance in a Dalmatian Type 2 Diabetic Population.Nutrients · 2025Article
- Early-life famine exposure and subsequent risk of chronic disease comorbidity in later adulthood: the role of social activities.Frontiers in nutrition · 2025Article
- Article
- Intra-Individual Variations in How Insulin Sensitivity Responds to Long-Term Exercise: Predictions by Machine Learning Based on Large-Scale Serum Proteomics.Metabolites · 2024Article
- Positive Effects of Physical Activity on Insulin Signaling.Current issues in molecular biology · 2024Review
- Exploratory integrated analysis of circulating exosomal miRNA and tissue mRNA related to long-term physical activity for more than 25 years: a bioinformatics study.European journal of applied physiology · 2023Article
- The Effects of Exercise Habit on Albuminuria and Metabolic Indices in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2022Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin became available for the treatment of patients with diabetes 100 years ago, and soon thereafter it became evident that the biological response to its actions differed markedly between individuals. This prompted extensive research into insulin action and resistance (IR), resulting in the universally agreed fact that IR is a core finding in patients with type 2 diabetes mellitus (T2DM). T2DM is the most prevalent form of diabetes, reaching epidemic proportions worldwide. Physical activity (PA) has the potential of improving IR and is, therefore, a cornerstone in the prevention and treatment of T2DM. Whereas most research has focused on the acute effects of PA, less is known about the effects of long-term PA on IR. Here, we describe a model of potential mechanisms behind reduced IR after long-term PA to guide further mechanistic investigations and to tailor PA interventions in the therapy of T2DM. The development of such interventions requires knowledge of normal glucose metabolism, and we briefly summarize an integrated physiological perspective on IR. We then describe the effects of long-term PA on signaling molecules involved in cellular responses to insulin, tissue-specific functions, and whole-body IR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.