ArticleJournal of cardiovascular development and disease2022
Coronary Artery Disease and Atrial Fibrillation: A Bidirectional Mendelian Randomization Study.
Article in Journal of cardiovascular development and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Impact of Atrial Fibrillation on Hospital Outcomes in NSTEMI Patients: A Retrospective Cohort Study.Journal of community hospital internal medicine perspectives · 2026Article
- Cardiovascular health and risks of atrial fibrillation and its prognosis.American journal of preventive cardiology · 2025Article
- Association of single and multiple cardiometabolic diseases with atrial fibrillation: a prospective cohort study.Open heart · 2025Article
- Atrial Fibrillation as an Independent Predictor of Myocardial Ischemia.Medicina (Kaunas, Lithuania) · 2025Article
- Metabolic syndrome worsens sarcopenia and reduces nutritional therapy benefits in advanced gastric cancer.Frontiers in nutrition · 2025Article
- Pathophysiology, Diagnosis, and Management of Coronary Artery Disease in the Setting of Atrial Fibrillation.Journal of the American Heart Association · 2024Review
- Spectrum of Non-Obstructive Coronary Artery Disease and Its Relationship with Atrial Fibrillation.Journal of clinical medicine · 2024Review
- Identification of potential biomarkers for atrial fibrillation and stable coronary artery disease based on WGCNA and machine algorithms.BMC cardiovascular disorders · 2024Article
- NSTEMI mortality and hospital outcomes in patients with atrial fibrillation: A propensity score-matched analysis.International journal of cardiology. Heart & vasculature · 2024Article
- New-onset atrial fibrillation among COVID-19 patients: A narrative review.World journal of critical care medicine · 2023Review
- Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants.Cardiovascular diabetology · 2023Article
- The bidirectional association between atrial fibrillation and myocardial infarction.Nature reviews. Cardiology · 2023Review
- Article
- Atrial fibrillation and coronary artery disease: An integrative review focusing on therapeutic implications of this relationship.World journal of cardiology · 2023Review
- New Perspectives on Risk Stratification and Treatment in Patients with Atrial Fibrillation: An Analysis of Recent Contributions on theJournal of cardiovascular development and disease · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Background: Several works of observational clinical research indicate that coronary artery disease (CAD) and atrial fibrillation (AF) aggravate each other. However, it is unknown whether these associations reveal independent causal processes. Objective: The present study aimed to evaluate causal associations between CAD and AF using two-sample Mendelian randomization (TSMR) analysis. Methods: Summary-level Genome-wide association study (GWAS) data for CAD were obtained from the CARDIoGRAMplusC4D consortium, including 60,801 patients and 123,504 controls. General data for AF were acquired from the largest meta-analysis, comprising of 60,620 patients with AF and 970,216 non-cases. After data harmonization, three different methods—inverse-variance weighted (IVW), MR-Egger, and weighted-median—were applied for TSMR analysis. Results: The calculated ORs (95% CIs) for AF using IVW, MR-Egger, and weighted-median analysis were 1.11 (1.05, 1.17; p-value < 0.001), 1.14 (1.00, 1.29; p-value = 0.049), and 1.13 (1.08, 1.19; p-value < 0.001), respectively; for CAD, the results were 1.01 (0.97, 1.04; p-value = 0.76), 0.95 (0.89, 1.02; p-value = 0.15), and 1.00 (0.95, 1.05; p-value = 0.97). Conclusion: This comprehensive TSMR analysis provides evidence that patients with CAD are associated with an increased risk of AF. However, no causal association was found between patients with AF and the risk of CAD. These findings benefit clinical decision-making. Early heart-rhythm monitoring should be performed in patients with CAD. The prevention and treatment of AF complications such as thrombosis may be essential to reduce the incidence of CAD in AF patients.
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