Evidence map›Paper›PMID 35323481›Full record

ArticleMarine drugs2022

Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts.

Noelia González-Ballesteros, Lara Diego-González, Mariano Lastra-Valdor, Maria Grimaldi, Antonella Cavazza, Franca Bigi, M Carmen Rodríguez-Argüelles, Rosana Simón-Vázquez

Abstract read
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Noelia González-BallesterosCINBIO, Departamento de Química Inorgánica, Universidade de Vigo, 36310 Vigo, Spain.ORCID 0000-0001-5514-1984
Lara Diego-GonzálezCINBIO, Immunology Group, Universidade de Vigo, 36310 Vigo, Spain.
Mariano Lastra-ValdorCIM, Universidade de Vigo, 36331 Vigo, Spain.ORCID 0000-0003-2738-2056
Maria GrimaldiDipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, 43124 Parma, Italy.ORCID 0000-0002-3040-1302
Antonella CavazzaDipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, 43124 Parma, Italy.ORCID 0000-0002-2885-4839
Franca BigiDipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, 43124 Parma, Italy.
M Carmen Rodríguez-ArgüellesCINBIO, Departamento de Química Inorgánica, Universidade de Vigo, 36310 Vigo, Spain.ORCID 0000-0003-4415-3204
Rosana Simón-VázquezCINBIO, Immunology Group, Universidade de Vigo, 36310 Vigo, Spain.ORCID 0000-0001-8963-6547

Funding

Xunta de Galicia ED431C 2018/54-GRC.
6 · The paper itself

Abstract

This study reports on the green and cost-efficient synthesis of gold nanoparticles from three different red algae extracts. The nanoparticles synthesized were fully characterized by UV-Vis spectroscopy, HRTEM, and Z-potential. Relevant components occurring in the extracts, such as polysaccharides or phenolic content, were assessed by analytical techniques such as spectrophotometric assays and liquid chromatography. Finally, the antioxidant, antitumoral, and anti-inflammatory potential of both the extracts and the gold nanoparticles synthesized were analyzed in order to determine a possible synergistic effect on the nanoparticles. The results obtained confirmed the obtainment of gold nanoparticles with significant potential as immunotherapeutic agents. The therapeutic potential of these nanoparticles could be higher than that of inert gold nanoparticles loaded with bioactive molecules since the former would allow for higher accumulation into the targeted tissue.

Indexed as

Antineoplastic AgentsAntioxidantsApoptosisCell LineComplex MixturesCytokinesGoldHumansImmunologic FactorsMetal NanoparticlesPhenolsPolysaccharidesReactive Oxygen SpeciesRhodophytaAntineoplastic AgentsAntioxidantsComplex MixturesCytokinesGoldImmunologic FactorsPhenolsPolysaccharidesReactive Oxygen Speciesanti-inflammatory activityantioxidant activityantitumoral activityChondrus crispusGelidium corneumgold nanoparticlesgreen synthesisPorphyra linearis

Identifiers

PMID35323481
PMCPMC8953345

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.