Evidence map›Paper›PMID 35323479›Full record

ArticleMarine drugs2022

Structural and Molecular Characterization of Squalene Synthase Belonging to the Marine Thraustochytrid Species

Sachin Vyas, Maurizio Bettiga, Ulrika Rova, Paul Christakopoulos, Leonidas Matsakas, Alok Patel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sachin VyasBiochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental, and Natural Resource Engineering, Luleå University of Technology, 97187 Luleå, Sweden.ORCID 0000-0001-9732-4172
Maurizio BettigaDepartment of Biological Engineering, Chalmers University of Technology, 41296 Gothenberg, Sweden.ORCID 0000-0001-5934-8720
Ulrika RovaBiochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental, and Natural Resource Engineering, Luleå University of Technology, 97187 Luleå, Sweden.ORCID 0000-0001-7500-2367
Paul ChristakopoulosBiochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental, and Natural Resource Engineering, Luleå University of Technology, 97187 Luleå, Sweden.
Leonidas MatsakasBiochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental, and Natural Resource Engineering, Luleå University of Technology, 97187 Luleå, Sweden.ORCID 0000-0002-3687-6173
Alok PatelBiochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental, and Natural Resource Engineering, Luleå University of Technology, 97187 Luleå, Sweden.ORCID 0000-0002-5285-1136
Luleå University of Technology · SEChalmers University of Technology · SE

Funding

Kempe Foundation JCK-2115 L3Swedish Research Council 2020-01028
6 · The paper itself

Abstract

The marine microorganisms thraustochytrids have been explored for their potential in the production of various bioactive compounds, such as DHA, carotenoids, and squalene. Squalene is a secondary metabolite of the triterpenoid class and is known for its importance in various industrial applications. The bioinformatic analysis for squalene synthase (SQS) gene (the first key enzyme in the tri-terpenoid synthesis pathway), that is prevailing among thraustochytrids, is poorly investigated. In-silico studies combining sequence alignments and bioinformatic tools helped in the preliminary characterization of squalene synthases found in

Indexed as

Amino Acid SequenceAquatic OrganismsBinding SitesComputational BiologyFarnesyl-Diphosphate FarnesyltransferaseLigandsModels, MolecularMolecular StructureStramenopilesFarnesyl-Diphosphate FarnesyltransferaseLigandsAurantiochytriumbioinformatic analysismarine thraustochytridssqualenesqualene synthase

Identifiers

PMID35323479
PMCPMC8955342
OpenAlexW4214683275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.