Evidence map›Paper›PMID 35323443›Full record

ArticleBiosensors2022

Applying Machine Learning with Localized Surface Plasmon Resonance Sensors to Detect SARS-CoV-2 Particles.

Jiawei Liang, Wei Zhang, Yu Qin, Ying Li, Gang Logan Liu, Wenjun Hu

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jiawei LiangSchool of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Wei ZhangSchool of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Yu QinSchool of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Ying LiSchool of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Gang Logan LiuSchool of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Wenjun HuSchool of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0001-8563-8844
Huazhong University of Science and Technology · CN

Funding

Fundamental Research Funds for the Central Universities 2019kfyXMPY002Major Research Program of National Natural Science Foundation of China 91959107 91959107National Key R&D Program of China 2020YFC0861900National Nature Science Foundation of China 82072735
6 · The paper itself

Abstract

The sudden outbreak of COVID-19 rapidly developed into a global pandemic, which caused tens of millions of infections and millions of deaths. Although SARS-CoV-2 is known to cause COVID-19, effective approaches to detect SARS-CoV-2 using a convenient, rapid, accurate, and low-cost method are lacking. To date, most of the diagnostic methods for patients with early infections are limited to the detection of viral nucleic acids via polymerase chain reaction (PCR), or antigens, using an enzyme-linked immunosorbent assay or a chemiluminescence immunoassay. This study developed a novel method that uses localized surface plasmon resonance (LSPR) sensors, optical imaging, and artificial intelligence methods to directly detect the SARS-CoV-2 virus particles without any sample preparation. The virus concentration can be qualitatively and quantitatively detected in the range of 125.28 to 106 vp/mL through a few steps within 12 min with a limit of detection (LOD) of 100 vp/mL. The accuracy of the SARS-CoV-2 positive or negative assessment was found to be greater than 97%, and this was demonstrated by establishing a regression machine learning model for the virus concentration prediction (R2 > 0.95).

Indexed as

COVID-19SARS-CoV-2Artificial IntelligenceHumansMachine LearningSurface Plasmon ResonanceLSPR sensormachine learningmicroscopic imagingSARS-CoV-2

Identifiers

PMID35323443
PMCPMC8946137
OpenAlexW4220959375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.