Evidence map›Paper›PMID 35323297›Full record

ArticleGels (Basel, Switzerland)2022

Complexation of DNA with Thermoresponsive Charged Microgels: Role of Swelling State and Electrostatics.

Julia Maldonado-Valderrama, Yan Yang, Maykel Jiménez-Guerra, Teresa Del Castillo-Santaella, José Ramos, Alberto Martín-Molina

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Julia Maldonado-ValderramaDepartamento de Física Aplicada, Universidad de Granada, Campus de Fuentenueva sn, 18071 Granada, Granada, Spain.ORCID 0000-0001-6372-723X
Yan YangDepartamento de Física Aplicada, Universidad de Granada, Campus de Fuentenueva sn, 18071 Granada, Granada, Spain.
Maykel Jiménez-GuerraDepartamento de Física Aplicada, Universidad de Granada, Campus de Fuentenueva sn, 18071 Granada, Granada, Spain.ORCID 0000-0002-1778-8805
Teresa Del Castillo-SantaellaDepartamento de Física Aplicada, Universidad de Granada, Campus de Fuentenueva sn, 18071 Granada, Granada, Spain.ORCID 0000-0002-8387-5560
José RamosIQLIT Emulsiones Poliméricas S.L.U., Autovía Tarragona-Salou Km 3,8., 43110 La Canonja, Tarragona, Spain.
Alberto Martín-MolinaDepartamento de Física Aplicada, Universidad de Granada, Campus de Fuentenueva sn, 18071 Granada, Granada, Spain.ORCID 0000-0001-8023-8665
Universidad de Granada · ES

Funding

Consejería de Transformación Económica, Industria, Conocimiento y Universidades (PAIDI2020). PY20_00138MCIN/AEI/10.13039/501100011033 and, by "ERDF A way of making Europe" PID2020-631-116615RA-647 I00MCIN/AEI/10.13039/501100011033 and, by "ERDF A way of making Europe" RTI2018-101309-B-C21
6 · The paper itself

Abstract

Micro- and nanogels are being increasingly used to encapsulate bioactive compounds. Their soft structure allows large loading capacity while their stimuli responsiveness makes them extremely versatile. In this work, the complexation of DNA with thermoresponsive microgels is presented. To this end, PEGylated charged microgels based on poly-N-isopropylacrylamide have been synthesized, allowing one to explore the electrostatics of the complexation. Cationic microgels complexate spontaneously by electrostatic attraction to oppositely charged DNA as demonstrated by electrophoretic mobility of the complexes. Then, Langmuir monolayers reveal an increased interaction of DNA with swollen microgels (20 °C). Anionic microgels require the presence of multivalent cations (Ca

Indexed as

compression isothermsDNAelectrophoretic mobilityhydrodynamic diametermicrogelmonolayersurface pressuresurface tension

Identifiers

PMID35323297
PMCPMC8955517
OpenAlexW4220825681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.